Explore the synergism of sedative dose medetomidine with tramadol to induce analgesic effects in rabbits
Other Title(s)
تأثيرات الجرعة تحت المسكنة ( المسدره) للميديتوميدين و الترامدول معا لأحداث التسكين في الأرانب
Author
al-Mashhadani, Mahmud Bashir Mahmud
Source
Basrah Journal of Veterinary Research
Issue
Vol. 15, Issue 2 (31 Dec. 2016), pp.97-110, 14 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Topics
Abstract EN
The study was designed to evaluate the analgesic effects of Medetomidine and Tramadol in rabbits, to detect the best dose (as onset and duration) for antinociceptive in this model, also evaluate the antinociceptive effect as sedative doses in these drugs as a mixture by using electrical stimulator.
Administration of Medetomidine alone at 200 μg\kg B.W.
(I.M) and Tramadol alone at 2 mg \ kg B.W.
(I.P) were the best doses for relief pain induced by electrical stimuli.
There was increased in the voltage change for pain ( 15, 30, 45, 60, 75, 90 minutes) in comparison with control and other doses for each drug.
Administration of Medetomidine at 50 μg\ kg B.W.
(I.M) with Tramadol at 0.5 mg\ kg B.W.
I.P) significantly referred to synergism of the antinociceptive effect which induced analgesia in 100 % of the rabbits in comparison with other groups for each drug alone (at the same analgesic doses) without any overt side effects and without differences in glucose, glutathione, ALT and AST level in animals.
The data of this study demonstrated the mixture of Medetomidine and Tramadol at low doses (subanalgesic doses) had a typical synergistic effect (super-additive) for inducing good and safe analgesia as well as its skeletal muscle relaxation in rabbits
American Psychological Association (APA)
al-Mashhadani, Mahmud Bashir Mahmud. 2016. Explore the synergism of sedative dose medetomidine with tramadol to induce analgesic effects in rabbits. Basrah Journal of Veterinary Research،Vol. 15, no. 2, pp.97-110.
https://search.emarefa.net/detail/BIM-778968
Modern Language Association (MLA)
al-Mashhadani, Mahmud Bashir Mahmud. Explore the synergism of sedative dose medetomidine with tramadol to induce analgesic effects in rabbits. Basrah Journal of Veterinary Research Vol. 15, no. 2 (2016), pp.97-110.
https://search.emarefa.net/detail/BIM-778968
American Medical Association (AMA)
al-Mashhadani, Mahmud Bashir Mahmud. Explore the synergism of sedative dose medetomidine with tramadol to induce analgesic effects in rabbits. Basrah Journal of Veterinary Research. 2016. Vol. 15, no. 2, pp.97-110.
https://search.emarefa.net/detail/BIM-778968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 106-110
Record ID
BIM-778968