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N-ras and k-ras mutations among some Iraqi patients with acute lymphoblastic leukemia
Joint Authors
al-Faysal, Abd al-Husayn Muwayt
Tubal, Khalid
Abd al-Husayn, Nuriyah
al-Amili, Wiam Ahmad
Source
Kufa Journal for Veterinary Medical Sciences
Issue
Vol. 7, Issue 1B (30 Jun. 2016), pp.87-96, 10 p.
Publisher
University of Kufa Faculty of Veterinary Medicine
Publication Date
2016-06-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Somatic mutations which influence the activity of RAS genes, n-, h-, and k-ras, are recognized mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers.
This persuades to search in coding genes suspected to be contributing to leukemogenesis such as n-ras and k-ras mutations that may associate with acute lymphoblastic leukemia for some Iraqi patients using a combination of high resolution melting-polymerase chain reaction (HRM-PCR) scanning with sequence analysis .
This study was carried out on fifty Iraqi patients (34 male, 16 female), (2-70 years of age) with acute lymphoblastic leukemia (ALL) , including 20 pre-treated , 15 under-treated and 15 relapsed patients compared with a sample consisted of 50 apparently healthy individuals as control group collected randomly from population living in Baghdad (4 - 66 years of age).
Of 50 ALL Iraqi patients , 6 patients were identified with an abnormal melting curve showing low frequency of ras genes mutations , this result is translated a poor prognostic for ras mutations in ALL .
According to the results of this study the c.34 in exon 2 (codon 12) was a hot spot for n-ras mutations and c.35 in exon 2 (codon 12) was a hot spot for k-ras mutations in ALL Iraqi patients , while no codon 61 mutations were detected for either n-ras or k-ras gene.
American Psychological Association (APA)
al-Amili, Wiam Ahmad& al-Faysal, Abd al-Husayn Muwayt& Abd al-Husayn, Nuriyah& Tubal, Khalid. 2016. N-ras and k-ras mutations among some Iraqi patients with acute lymphoblastic leukemia. Kufa Journal for Veterinary Medical Sciences،Vol. 7, no. 1B, pp.87-96.
https://search.emarefa.net/detail/BIM-785230
Modern Language Association (MLA)
al-Amili, Wiam Ahmad…[et al.]. N-ras and k-ras mutations among some Iraqi patients with acute lymphoblastic leukemia. Kufa Journal for Veterinary Medical Sciences Vol. 7, no. 1B (2016), pp.87-96.
https://search.emarefa.net/detail/BIM-785230
American Medical Association (AMA)
al-Amili, Wiam Ahmad& al-Faysal, Abd al-Husayn Muwayt& Abd al-Husayn, Nuriyah& Tubal, Khalid. N-ras and k-ras mutations among some Iraqi patients with acute lymphoblastic leukemia. Kufa Journal for Veterinary Medical Sciences. 2016. Vol. 7, no. 1B, pp.87-96.
https://search.emarefa.net/detail/BIM-785230
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 94-96
Record ID
BIM-785230