Synthesis, characterization and investigation the antibacterial activity of new heterocyclic compounds derived from 4-(4-methoxy benzoyloxy) benzaldehydethiosemicarbazone
Other Title(s)
تحضير و تشخيص و فحص الفعالية البكتيرية للمركبات الحلقية غير المتجانسة الجديدة و المشتقة من 4 (4-ميثوكسي بنزويلوكسي) بنزالديهايد ثايوسيمكياربزون
Joint Authors
Baqir, Raja Kazim
Jamil, Nibras Muzaffar
al-Jazrawi, Jumbad Hurmuz Tuma Musa
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 30, Issue 1 (30 Apr. 2017), pp.155-168, 14 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-04-30
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Abstract EN
4-Thiazolidinone were synthesized by three steps,the reaction of ansoyl chloride with 4- hydroxy benzaldehyde to give 4-(4`-methoxy benzoyloxy) benzaldehyde[I].The reaction of later compound with thiosemicarbazideled to formation thiosemicarbazon [II] and the reacted thiosemicarbazone with chloro acetic acid in CH3CO2Na medium to yield 4- thiazelidinone compound[III].The 4-thiazolidinone [III]was used as a key intermediates to synthesis new compounds, compound[IV] synthesized from the reaction [III] with acetic anhydride, while the reaction of compound [III] with amines to yield azo compound[V]a,b,c.
The azo compound reacted with benzoyl chloride or anisole chloride in basic medium to get a new esters compound[VI]a,b.
Also, synthesis oxazepine compound[VII],[VIII] and [IX]a,b,c from heating schiff bases [III],[IV][V]a,b,c with phthalic anhydride in dry benzene in cyclo-addition reaction.
The compounds were characterized by FTIR and 1HNMR (of some of them), the synthesized compounds have been screened for their six species of bacteria were used in this study as tested organisms.
These are pseudomonas aeruginosa, klebseilla, providencea, Serratiamarcescens(Gram negative) and staphylococcus epidermidis, Bacillus(Gram positive).
American Psychological Association (APA)
Jamil, Nibras Muzaffar& Baqir, Raja Kazim& al-Jazrawi, Jumbad Hurmuz Tuma Musa. 2017. Synthesis, characterization and investigation the antibacterial activity of new heterocyclic compounds derived from 4-(4-methoxy benzoyloxy) benzaldehydethiosemicarbazone. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 30, no. 1, pp.155-168.
https://search.emarefa.net/detail/BIM-790571
Modern Language Association (MLA)
Jamil, Nibras Muzaffar…[et al.]. Synthesis, characterization and investigation the antibacterial activity of new heterocyclic compounds derived from 4-(4-methoxy benzoyloxy) benzaldehydethiosemicarbazone. Ibn al-Haitham Journal for Pure and Applied Science Vol. 30, no. 1 (Apr. 2017), pp.155-168.
https://search.emarefa.net/detail/BIM-790571
American Medical Association (AMA)
Jamil, Nibras Muzaffar& Baqir, Raja Kazim& al-Jazrawi, Jumbad Hurmuz Tuma Musa. Synthesis, characterization and investigation the antibacterial activity of new heterocyclic compounds derived from 4-(4-methoxy benzoyloxy) benzaldehydethiosemicarbazone. Ibn al-Haitham Journal for Pure and Applied Science. 2017. Vol. 30, no. 1, pp.155-168.
https://search.emarefa.net/detail/BIM-790571
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 162-167
Record ID
BIM-790571