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Glutathione S-transferase gene with susceptibility to juvenile idiopathic arthritis
Other Title(s)
جين الجلوتاشيون و الاستعداد للإصابة بالروماتويد في الأطفال
Joint Authors
Izzat, Muhammad Hisham M.
Abu Ajwah, Sarah Hasan
Abu Kurayshah, Halah Ali
al-Jabali, Huwayda Husni
Source
Issue
Vol. 19, Issue 71 (30 Apr. 2016), pp.33-37, 5 p.
Publisher
Ain Shams University Faculty of Graduate Studies for Childhood
Publication Date
2016-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction: Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease of unclear etiology.
It is the most common inflammatory arthritis worldwide with major individual and health service coast.
GSTs play important roles in detoxification mechanisms.
It is known to be polymorphic and the presence of polymorphisms has been implicated in susceptibility of JIA.
Aim: The aim of this study was to explore the association between GST gene and susceptibility to JIA.
Subject& methods: 40 patients with JIA and 40 apparently healthy controls matched with age and sex were genotyped using allelic discrimination by PCR.
Results: the frequency of GSTM1 null genotype polymorphism was significantly higher in JIA patients than in controls (OR= 0.4, CI= 0.16- 0.98, P= 0.04) No significant association was found regarding GSTT1 null gene polymorphisms in JIA patients (OR- 0.417, CI= 0.15-1.13, P= 0.8).
GSTM 1null gene polymorphism is more prevalent in females than males {P= 0.004), whereas no significant association was found in GSTT1 gene polymorphism (p= 0.4).
Conclusion: Higher frequency of GSTM1 null genotype polymorphism in patients of JIA suggesting that it might be associated with susceptibility of JIA, severity and outcome.
GSTT1 null gene polymorphism had no association with JIA susceptibility.
American Psychological Association (APA)
al-Jabali, Huwayda Husni& Izzat, Muhammad Hisham M.& Abu Ajwah, Sarah Hasan& Abu Kurayshah, Halah Ali. 2016. Glutathione S-transferase gene with susceptibility to juvenile idiopathic arthritis. Journal of Childhood Studies،Vol. 19, no. 71, pp.33-37.
https://search.emarefa.net/detail/BIM-809112
Modern Language Association (MLA)
Izzat, Muhammad Hisham M.…[et al.]. Glutathione S-transferase gene with susceptibility to juvenile idiopathic arthritis. Journal of Childhood Studies Vol. 19, no. 71 (Apr. 2016), pp.33-37.
https://search.emarefa.net/detail/BIM-809112
American Medical Association (AMA)
al-Jabali, Huwayda Husni& Izzat, Muhammad Hisham M.& Abu Ajwah, Sarah Hasan& Abu Kurayshah, Halah Ali. Glutathione S-transferase gene with susceptibility to juvenile idiopathic arthritis. Journal of Childhood Studies. 2016. Vol. 19, no. 71, pp.33-37.
https://search.emarefa.net/detail/BIM-809112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 36-37
Record ID
BIM-809112