![](/images/graphics-bg.png)
Breast cancer subtypes among Iraqi patients : identified by their ER, PR and HER2 status
Joint Authors
Tawfiq, Furat N.
Mullah, Faysal H.
al-Ulwan, Nada Abd al-Sahib
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 59, Issue 4 (31 Dec. 2017)5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background: Breast cancer ranks the first among the Iraqi population since three decades and is currently forming a major public health problem being the second cause of death women.
Novel management of breast cancer depends upon precise evaluation of their molecular subtypes; identified by Hormone (Estrogen and Progesterone) receptors and HER2 contents of the primary tumor.
Objective: To assess the rates of the different molecular breast cancer subtypes in the examined tissue specimens belonging to females diagnosed with breast cancer in Iraq; correlating the findings with those reported in the literature at the regional and global levels.
Patients and Methods: This retrospective study documented the findings of tissue biopsy examination belonging to 686 female patients diagnosed with breast cancer.
Formalin fixed paraffin-embedded blocks were utilized to assess the availability of Estrogen receptors (ER), Progesterone receptors (PR) and HER2 expressions through semi quantitative immuno-histochemical staining technique.
Breast carcinomas were classified into four main molecular subtypes: Luminal A: ER/PR(+) / HER2(-), Luminal B/Triple Positive: ER/PR(+) / HER2(+), Non-Luminal HER-2 enriched: ER/PR(-) / HER2(+) and Non-Luminal/Triple Negative: ER/PR(-) and HER2(-).
Other phenotypes included: ER(+)/PR(-) / HER2(+), ER(-)/PR(+) / HER2 (+), ER (+)/PR (-) / HER2 (-) and ER (-)/PR (+) / HER2 (-).
Results: Out of the exanimated cases of breast carcinomas, the registered rates of positive ER, PR and HER2 tumor contents in this study were 67.8%, 65.3% and 29.4% respectively.
The main identified phenotype was the Luminal A in 309 cases (45%).
That was followed by the Triple Negative in 107 cases (15.6%) and Triple Positive/Luminal B (96 cases, 14%), while 71 cases (10.3%) were HER2 enriched.
The corresponding rates of the (E+/P-/H+), (E-/P+/H+), (E+/P-/H-) and (E-/P+/H-) subtypes were 3.1%, 2.0%., 5.7% and 4.2% respectively.
Differences in in the expressions of these IHC molecular markers are illustrated among different countries.
Conclusions: Due to the displayed variations in the socio-demographic characteristics and biological risk factors among patients in different populations, it is mandatory to identify the molecular marker subtypes of breast cancer expressions in order to assess the impact of management and response to therapy.
The routine documentation of their patterns in the cancer registry reports and published research ensures the validity and reliability of the presented clinical data.
American Psychological Association (APA)
al-Ulwan, Nada Abd al-Sahib& Tawfiq, Furat N.& Mullah, Faysal H.. 2017. Breast cancer subtypes among Iraqi patients : identified by their ER, PR and HER2 status. Journal of the Faculty of Medicine Baghdad،Vol. 59, no. 4.
https://search.emarefa.net/detail/BIM-809818
Modern Language Association (MLA)
al-Ulwan, Nada Abd al-Sahib…[et al.]. Breast cancer subtypes among Iraqi patients : identified by their ER, PR and HER2 status. Journal of the Faculty of Medicine Baghdad Vol. 59, no. 4 (2017).
https://search.emarefa.net/detail/BIM-809818
American Medical Association (AMA)
al-Ulwan, Nada Abd al-Sahib& Tawfiq, Furat N.& Mullah, Faysal H.. Breast cancer subtypes among Iraqi patients : identified by their ER, PR and HER2 status. Journal of the Faculty of Medicine Baghdad. 2017. Vol. 59, no. 4.
https://search.emarefa.net/detail/BIM-809818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 304-305
Record ID
BIM-809818