Determination of DNA damage induced after bitter orange (Citrus aurantium) essential oil administrated in vivo
Other Title(s)
تحديد مدى تضرر المادة الوراثية DNA داخل الجسم الحي بعد التجريع الفموي لزيت النارنج (Citrus aurantium) العطري
Joint Authors
Abd al-Ghani, Zaynab Sad
Jafar, Tibah Hikmat
Kamil, Saba
Amir, Rasha Abd
Abd al-Latif, Aminah
Barakat, Nadiyah Tariq
al-Rikabi, Nahi Yusuf Yasin
Tawfiq, Amir Talib
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 9, Issue 2 (31 Dec. 2016), pp.176-180, 5 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2016-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
This research was carried out in order to investigate whether the puri ed bitter orange (Citrus aurantium) volatile oil puri- ed from peels has a potentiality to induced DNA damage if administrated orally in vivo.
White adult male rats (180- 250g) were divided into ve groups each group with ve individuals.
The rst three groups administrated three different con- centration of the puri ed citrus essential oil 100, 200 and 300μl/ kg Body weight (Bwt).
The fourth group administrated olive oil and served as positive control group.
The fth was administrated water as negative control group.
Dosing for all groups were two times weekly for one month period.
To detected DNA damage, alkaline single cell gel electrophoresis (SCGE) for the blood samples was carried out for all groups.
Parameters of nuclear olive moment, comet tail length, and DNA on comet tail were calculated.
Results showed that there were no signi cant differences between treated and control untreated groups as well as olive oil administrated group.
These results indicate that citrus volatile oil has no genotoxic effect and it was safe and tolerable in the highest dose used for the speci ed period of time conducted.
American Psychological Association (APA)
Abd al-Ghani, Zaynab Sad& Barakat, Nadiyah Tariq& Tawfiq, Amir Talib& al-Rikabi, Nahi Yusuf Yasin& Jafar, Tibah Hikmat& Kamil, Saba…[et al.]. 2016. Determination of DNA damage induced after bitter orange (Citrus aurantium) essential oil administrated in vivo. Iraqi Journal of Cancer and Medical Genetics،Vol. 9, no. 2, pp.176-180.
https://search.emarefa.net/detail/BIM-818973
Modern Language Association (MLA)
Abd al-Ghani, Zaynab Sad…[et al.]. Determination of DNA damage induced after bitter orange (Citrus aurantium) essential oil administrated in vivo. Iraqi Journal of Cancer and Medical Genetics Vol. 9, no. 2 (2016), pp.176-180.
https://search.emarefa.net/detail/BIM-818973
American Medical Association (AMA)
Abd al-Ghani, Zaynab Sad& Barakat, Nadiyah Tariq& Tawfiq, Amir Talib& al-Rikabi, Nahi Yusuf Yasin& Jafar, Tibah Hikmat& Kamil, Saba…[et al.]. Determination of DNA damage induced after bitter orange (Citrus aurantium) essential oil administrated in vivo. Iraqi Journal of Cancer and Medical Genetics. 2016. Vol. 9, no. 2, pp.176-180.
https://search.emarefa.net/detail/BIM-818973
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-818973