تأثير الكاراجينان المكبرت المستخلص من الطحلب Laurencia papillosa على تثبيط نمو الخلايا البشرية الدبقية السرطانية T98G

الملخص EN

The high biodiversity of marine ecosystems makes it a good source of numerous bioactive molecules useful in pharmacological and therapeutic applications.

Many studies have reported that marine algae consumption is linked to law cancer incidences in countries that traditionally consume marine products.

Seaweeds are considered as a riche source of sulphated polysaccharides such as carrageenans.

In this study, the biological activity of sulphated carrageenan (ESC) extracted from the red alga Laurencia papillosa on T98G cancer cell line was explored.

We studied the bio-effect of ESC and apoptosis on T98G cells through nuclear condensation and DNA fragmentation.

Gene expression study for caspase-3 and caspase-8 was measured using qPCR after ESC treatment.

This result was supported by flow cytometry technique which revealed an increase in ACTIVE CASPASE-3 protein levels in treated cells.

The presented data demonstrated that ESC is considered as a promising compound which could target the proliferation of glioblastoma cells.