Antioxidant, anticancer, apoptosis properties and chemical composition of black truffle Terfezia claveryi
Joint Authors
Dahham, Sad Sabir
Abd al-Majid, Aman Shah
Abd al-Majid, Amin Malik Shah
Ibrahim, Ahmad H.
al-Rawi, Sawsan S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 8 (31 Dec. 2018), pp.1524-1534, 11 p.
Publisher
Publication Date
2018-12-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Topics
Abstract EN
Desert truffles are seasonal and important edible fungi that grow wild in many countries around the world.
Truffles are natural food sources that have significant compositions.
In this work, the antioxidant, chemical composition, anticancer, and antiangiogenesis properties of the Terfezia claveryi truffle were investigated.
Solvent extractions of the T.
claveryi were evaluated for antioxidant activities using (DPPH, FRAP and ABTS methods).
The extracts cytotoxicity on the cancer cell lines (HT29, MCF-7, PC3 and U-87MG)was determined byMTTassay, while the anti-angiogenic efficacy was tested using ex-vivo assay.
All extracts showed moderate anticancer activities against all cancer cells (p< 0.05).
The hexane extract inhibited the brain cell line (U-87 MG) with an IC50 of 50 lg/ ml and significantly promoted cell apoptosis through the mitochondrial pathway and DNA fragmentation p< 0.001.
The ethanol extract demonstrated potent antioxidants; DPPH, FRAP, and ABTS with an IC50 value of 52, 48.5 and 64.7 lg/ml, respectively.
In addition, the hexane and ethyl acetate extract significantly (p<0.001) inhibited the sprouting of microvessels by 100% and 81.2%, at 100 lg/ml, respectively.
The GC analysis of the most active extract (hexane) showed the presence of several potent phytochemicals such as stigmasterol, beta-Sitosterol, squalene, lupeol, octadecadienoic acid, and oleic acid.
American Psychological Association (APA)
Dahham, Sad Sabir& al-Rawi, Sawsan S.& Ibrahim, Ahmad H.& Abd al-Majid, Aman Shah& Abd al-Majid, Amin Malik Shah. 2018. Antioxidant, anticancer, apoptosis properties and chemical composition of black truffle Terfezia claveryi. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1524-1534.
https://search.emarefa.net/detail/BIM-832829
Modern Language Association (MLA)
Dahham, Sad Sabir…[et al.]. Antioxidant, anticancer, apoptosis properties and chemical composition of black truffle Terfezia claveryi. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1524-1534.
https://search.emarefa.net/detail/BIM-832829
American Medical Association (AMA)
Dahham, Sad Sabir& al-Rawi, Sawsan S.& Ibrahim, Ahmad H.& Abd al-Majid, Aman Shah& Abd al-Majid, Amin Malik Shah. Antioxidant, anticancer, apoptosis properties and chemical composition of black truffle Terfezia claveryi. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1524-1534.
https://search.emarefa.net/detail/BIM-832829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1533-1534
Record ID
BIM-832829