Extraction of pure ketamine powder and study their analgesic effect as a gel on mice using a hot-plate test

Abstract EN

The present study was undertaken to extract ketamine powder from ketamine hydrochloride by precipitate ketamine.

After that we examine the purity of this powder by infra-red (FTIR) and ultra-violet(UV) spectroscopy.

ketamine gel in different concentrations was prepared ( 0.5 , 1 , 5 , 10 , 15 )% to evaluate the antinociceptive activity.

ketamine powder was seen is pure and this show in infra-red and ultra-violet scanner.

Ketamine gel at concentrations 0.5, 1, 5, 10,15) % produce antinociceptive in mice (5.6±2.2) (4.4±2.0) (8.2±4.3) (10.6±5.2) (8±2.1) second after 2 min respectively by using a hot plate test in comparison with control(2.4±2).

The percentage of maximum possible effect (MPE) increased from (9.9) % in control group to (23.3) (18.3) (34.2) (44.2) (33.3)% respectively according to the concentrations of ketamine gel after 2 min .

Purification of ketamine powder from ketamine solution and use as a gel to could be of value relief pain by topical application.