Effect of zuccagnia punctata Cav. (Fabaceae)‎ extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus : toxicity studies

Joint Authors

Alberto, M. R.
Isla, M. I.
Nuno, G.
Arena, M. E.
Zampini, I. C.

Source

Saudi Journal of Biological Sciences

Issue

Vol. 25, Issue 8 (31 Dec. 2018), pp.1713-1719, 7 p.

Publisher

Saudi Biological Society

Publication Date

2018-12-31

Country of Publication

Saudi Arabia

No. of Pages

7

Main Subjects

Biology

Topics

Abstract EN

Zuccagnia punctata Cav.

(Fabaceae), a native plant from Argentina has been used traditionally as medicinal species.

The aim of the study was to validate the antibiotic and antiinflammatory potential of Z.

punctata organic extract (ZpE) and the major compounds; 20,40-dihy droxy-30-methoxychalcone (DHMC), 20,40-dihydroxychalcone (DHC), 7-hydroxyflavanone (7-HF) and 3,7-dihydroxyflavone (DHF); using an in vitro model.

The antibiotic activity was determined using a broth microdilution method and the minimum inhibitory concentration (MIC) was determined.

The extract and the isolation compounds affect the normal growth of all assayed Staphylococcus aureus strains.

The MIC values for ZpE and isolated compounds were between 125 and 500 lg/mL and between 25 and 400 lg/mL, respectively, against all assayed strains.

The inhibitory effect of extract and isolated compounds on biofilm formation and on pro-inflammatory enzymes (sPLA2, COX-2, LOX) was analyzed.

The compound DHC was the most active on sPLA2 while DHF and DHMC showed the highest activity on LOX.

Both the extract and pure compounds except DHMC were active against COX-2.

It can be concluded that the phytocomplex and the pure compounds possessed antibiotic and anti-inflammatory activities under the conditions tested, and could be a good alternative therapy for infective and inflammatory processes.

American Psychological Association (APA)

Nuno, G.& Alberto, M. R.& Arena, M. E.& Zampini, I. C.& Isla, M. I.. 2018. Effect of zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus : toxicity studies. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1713-1719.
https://search.emarefa.net/detail/BIM-835027

Modern Language Association (MLA)

Nuno, G.…[et al.]. Effect of zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus : toxicity studies. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1713-1719.
https://search.emarefa.net/detail/BIM-835027

American Medical Association (AMA)

Nuno, G.& Alberto, M. R.& Arena, M. E.& Zampini, I. C.& Isla, M. I.. Effect of zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus : toxicity studies. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1713-1719.
https://search.emarefa.net/detail/BIM-835027

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1718-1719

Record ID

BIM-835027