Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals
Joint Authors
Ikhzaymi, Aishah
Khan, Isra
al-Musawi, Muna A.
Khan, Hasib A.
Sobki, Samiyah H.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 8 (31 Dec. 2018), pp.1729-1732, 4 p.
Publisher
Publication Date
2018-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM).
We determined the homeostatic model assessment insulin resistance (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in T2DM patients and non-diabetic subjects.
This study comprised a total of 47 T2DM patients and 38 non-diabetic controls.
Venous blood samples from all the subjects were collected and sera were analyzed for FBG, HbA1c, insulin and Cpeptide using an autoanalyzer.
HOMA-IR was calculated using the following equation: HOMA-IR = fasting insulin (μU/ml) fasting glucose (mmol/L)/22.5.
There was a significant increase in the levels of FBG and HbA1c in diabetic patients.
Although the levels of C-peptide and insulin did not differ significantly between the two groups, a significant increase in HOMA-IR was observed in T2DM patients.
Both insulin and C-peptide were significantly correlated with HOMA-IR.
In conclusion, C-peptide may serve as a simple and convenient predictor of HOMA-IR.
American Psychological Association (APA)
Khan, Hasib A.& Sobki, Samiyah H.& Ikhzaymi, Aishah& Khan, Isra& al-Musawi, Muna A.. 2018. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036
Modern Language Association (MLA)
Ikhzaymi, Aishah…[et al.]. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036
American Medical Association (AMA)
Khan, Hasib A.& Sobki, Samiyah H.& Ikhzaymi, Aishah& Khan, Isra& al-Musawi, Muna A.. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1730
Record ID
BIM-835036