Bioremediation of cadmium induced renal toxicity in rattus norvegicus by medicinal plant catharanthus roseus

Joint Authors

Abd Allah, al-Sayyid Fathi
Hashim, Abir
Tabassum, Baby
Bajaj, Priya

Source

Saudi Journal of Biological Sciences

Issue

Vol. 25, Issue 8 (31 Dec. 2018), pp.1739-1742, 4 p.

Publisher

Saudi Biological Society

Publication Date

2018-12-31

Country of Publication

Saudi Arabia

No. of Pages

4

Main Subjects

Biology

Topics

Abstract EN

Cadmium is the second most hazardous metals with bio-concentration factor (BCF) > 100 Although WHO permitted cadmium concentration in drinking water is 0.005 mg/L, yet the reality is far above to this limit because of industrial utility of this metal.

Oral exposure of cadmium to human results in dreadful symptoms of metabolic disorders especially in liver and kidneys.

Endogenous protection could be supported by some exogenous herbal supplement (viz., Catharanthus roseus in this case) to overcome the toxic effects.

Present Study has been designed to find out the functional renal changes under the effect of cadmium and Catharanthus roseus in the model organism albino rats.

Cadmium significantly (p > 0.01) increases the level of nitrogenous waste (Urea, BUN, Uric Acid and Creatinin), while decreases the serum protein profile in acute and sub-acute sets.

Urea concentration of control ranged from 16.56 to 17.72 mg/dl while that of Group-B and D were 19.84 to 20.87 mg/dl and 17.56 to 17.59 mg/dl respectively.

Similarly uric acid concentration ranged in control form 6.98 to 8.01 mg/dl in group-B from 7.58 to 10.25 mg/dl, in Group-D 8.02 to 8.59 mg/dl respectively.

Creatinin concentration ranged in control 0.57 to 0.65 mg/dl, in group-B 0.97 to 1.02 mg/dl, in group-D – 0.95 to 0.98 mg/dl respectively.

These results might be due to altered filtration rate of kidney because of protein disruption.

The studies conclude the efficient nephro-protection offered by Catharanthus roseus extract against Cadmium toxicity.

American Psychological Association (APA)

Hashim, Muhammad& Tabassum, Baby& Abd Allah, al-Sayyid Fathi& Hashim, Abir& Bajaj, Priya. 2018. Bioremediation of cadmium induced renal toxicity in rattus norvegicus by medicinal plant catharanthus roseus. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1739-1742.
https://search.emarefa.net/detail/BIM-835186

Modern Language Association (MLA)

Hashim, Muhammad…[et al.]. Bioremediation of cadmium induced renal toxicity in rattus norvegicus by medicinal plant catharanthus roseus. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1739-1742.
https://search.emarefa.net/detail/BIM-835186

American Medical Association (AMA)

Hashim, Muhammad& Tabassum, Baby& Abd Allah, al-Sayyid Fathi& Hashim, Abir& Bajaj, Priya. Bioremediation of cadmium induced renal toxicity in rattus norvegicus by medicinal plant catharanthus roseus. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1739-1742.
https://search.emarefa.net/detail/BIM-835186

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1742

Record ID

BIM-835186