The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

Joint Authors

Muthanna, Ramzi Ahmad
Abu al-Farah, Muhammad
al-Hamid, Fahd
Alallah, Muhammad Ibrahim
Bai, Fang
al-Shaykh, Muhammad Sulayman
al-Anzi, Khalid Mashai
Ali, Muhammad Ajmal
Lee, Joongku

Source

Saudi Journal of Biological Sciences

Issue

Vol. 25, Issue 8 (31 Dec. 2018), pp.1826-1833, 8 p.

Publisher

Saudi Biological Society

Publication Date

2018-12-31

Country of Publication

Saudi Arabia

No. of Pages

8

Main Subjects

Biology

Topics

Abstract EN

The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer, and then the drug that specifically toxic to the cancer cells further complicates the process of the development of the widely effective potential anticancer drug.

The side effects of the drug as well as the radiotherapy used for the treatment of cancer is severe; therefore, the search of the natural products from the sources of wild plants having anticancer potential is become immense importance today.

The ethno-medicinal survey undertaken in Al-Fayfa and Wadi-E-Damad region of southern Saudi Arabia revealed that the Caralluma retrospiciens (Ehrenb.) N.E.Br.

(family Apocynaceae) is being used for the treatment of cancer by the native inhabitants.

The biological evaluation of anticancer potential of bioassay-guided fractionations of methanolic extract of whole plant of C.

retrospiciens against human breast adenocarcinoma cell line (MCF-7) followed by characterization using spectroscopic methods confirmed the presence of methyl b-lilacinobioside, a novel active constituent reported for the first time from C.

retrospiciens, is capable of inhibition of cell proliferation and induction of apoptosis in MCF-7 cells by regulating ROS mediated autophagy, and thus validated the folkloric claim.

Based on a small-scale computational target screening, Topoisomerase II was identified as the potential binding target of methyl b-lilacinobioside.

American Psychological Association (APA)

Alallah, Muhammad Ibrahim& al-Hamid, Fahd& Bai, Fang& Muthanna, Ramzi Ahmad& al-Shaykh, Muhammad Sulayman& Abu al-Farah, Muhammad…[et al.]. 2018. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320

Modern Language Association (MLA)

Alallah, Muhammad Ibrahim…[et al.]. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320

American Medical Association (AMA)

Alallah, Muhammad Ibrahim& al-Hamid, Fahd& Bai, Fang& Muthanna, Ramzi Ahmad& al-Shaykh, Muhammad Sulayman& Abu al-Farah, Muhammad…[et al.]. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1832-1833

Record ID

BIM-835320