Single nucleotide polymorphism of IL1B gene (rs16944) in a sample of rheumatoid arthritis Iraqi patients
Other Title(s)
تعدد أشكال النيكميوتيدة المفردة لجين بين ابيضاض-بيتا 1(rs16944) في عينة من مرضى إلتهاب المفاصل الرثوي العراقيين
Joint Authors
Mahmud, Asil Shakir
Ad'hiah, Ali Husayn
al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab
Source
Issue
Vol. 59, Issue 2C (30 Jun. 2018), pp.1041-1045, 5 p.
Publisher
University of Baghdad College of Science
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Cytokines play a prominent role in etiology and pathogenesis of rheumatoid arthritis (RA), and one of these cytokines is interleukin-1β (IL-1β).
The association between IL1B gene single nucleotide polymorphism (SNP: rs16944) and rheumatoid arthritis (RA) in a sample of Iraqi patients was investigated.
Fifty-one RA patients (21 males and 30 females) were enrolled and their age range was 20 - 63 years (44.9 ± 1.5 years).
In addition to patients, 45 apparently healthy control subjects were also enrolled in the study.
They matched patients for ethnicity (Iraqis), gender (14 males and 31 females) and age (41.3 ± 1.3 years).
Analysis of Hardy-Weinberg equilibrium (HWE) in RA patients and controls revealed that the IL1B genotypes were consistent with the equilibrium, and no significant differences (p > 0.05) were observed between the observed and expected genotype frequencies.
Inspecting IL1B genotype and allele frequencies in RA patients and controls revealed that there were no significant variations between these frequencies, although a decreased frequency of T allele (67.7 vs.
73.3%) and an increased frequency of C allele (32.3vs.
26.7%) were observed in patients compared to controls.
In conclusion, the results are in favor of no association between IL1B gene SNP (rs16944) and RA in Iraqi population
American Psychological Association (APA)
Mahmud, Asil Shakir& al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab& Ad'hiah, Ali Husayn. 2018. Single nucleotide polymorphism of IL1B gene (rs16944) in a sample of rheumatoid arthritis Iraqi patients. Iraqi Journal of Science،Vol. 59, no. 2C, pp.1041-1045.
https://search.emarefa.net/detail/BIM-838033
Modern Language Association (MLA)
Mahmud, Asil Shakir…[et al.]. Single nucleotide polymorphism of IL1B gene (rs16944) in a sample of rheumatoid arthritis Iraqi patients. Iraqi Journal of Science Vol. 59, no. 2C (Jun. 2018), pp.1041-1045.
https://search.emarefa.net/detail/BIM-838033
American Medical Association (AMA)
Mahmud, Asil Shakir& al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab& Ad'hiah, Ali Husayn. Single nucleotide polymorphism of IL1B gene (rs16944) in a sample of rheumatoid arthritis Iraqi patients. Iraqi Journal of Science. 2018. Vol. 59, no. 2C, pp.1041-1045.
https://search.emarefa.net/detail/BIM-838033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1045
Record ID
BIM-838033