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The prognostic value of some epithelial-mesenchymal transition markers and metastasis-related markers in human transitional cell carcinoma of the bladder
Other Title(s)
التعبير عن بعض المعلمات الطلائية-الميزنكيمية و انتشار الأورام السرطانية للتنبؤ بمستقبل مرضى سرطان الخلايا الانتقالية للمثانة البولية
Author
Source
Issue
Vol. 15, Issue 3 (30 Sep. 2018), pp.244-252, 9 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2018-09-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Recent reports provided evidence that epithelial to mesenchymal transition (EMT) and some matrix metalloproteinases (MMPs) contribute to the invasion and metastasis of cancer cells.
This study investigated the expression pattern of some EMT markers (E-cadherin and Vimentin) and some MMPs (MMP-2 and MMP-9) in transitional cell carcinoma (TCC).
Fifty five paraffin embedded biopsies were included in this study.
Expression pattern of E-cadherin and Vimentin was evaluated by immunohistochemistry while cytoplasmic mRNA expression of both MMP-2 and MMP-9 were determined by in situ hybridization.
The expression of all markers were significantly increased with the increase of patient's age (≥ 50 years), and furthermore an increase in men expression when compared to women.
Interestingly, all healthy tissues showed positive E-cadherin expression while they did not show any expression of Vimentin, MMP-2 and MMP-9.
E-cadherin expression decreased, whereas expression of Vimentin increased according to the grade and stage of the tumor.
Similarly, both MMP-2 and MMP-9 expression were increased with the progression of TCC.
The current study conclude that a decrease in E-cadherin together with increased Vimentin, MMP-2 and MMP-9 are significant markers that correlate with poor prognosis of TCC.
American Psychological Association (APA)
Ismail, Mayy Khalil. 2018. The prognostic value of some epithelial-mesenchymal transition markers and metastasis-related markers in human transitional cell carcinoma of the bladder. Baghdad Science Journal،Vol. 15, no. 3, pp.244-252.
https://search.emarefa.net/detail/BIM-852858
Modern Language Association (MLA)
Ismail, Mayy Khalil. The prognostic value of some epithelial-mesenchymal transition markers and metastasis-related markers in human transitional cell carcinoma of the bladder. Baghdad Science Journal Vol. 15, no. 3 (2018), pp.244-252.
https://search.emarefa.net/detail/BIM-852858
American Medical Association (AMA)
Ismail, Mayy Khalil. The prognostic value of some epithelial-mesenchymal transition markers and metastasis-related markers in human transitional cell carcinoma of the bladder. Baghdad Science Journal. 2018. Vol. 15, no. 3, pp.244-252.
https://search.emarefa.net/detail/BIM-852858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 250-251
Record ID
BIM-852858