Association between adenosine receptor gene polymorphism and response to caffeine citrate treatment in apnea of prematurity : an Egyptian single-center study
Joint Authors
Zaydan, Nahlah
Mukhtar, Wisam A.
Allam, Rim M.
Hamid, Muna S.
Fawzi, Amal
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 66, Issue 4 (31 Dec. 2018), pp.115-120, 6 p.
Publisher
Egyptian Pediatric Association
Publication Date
2018-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Caffeine citrate is the methyl-xanthine of choice used in controlling apnea of prematurity (AOP).
Caffeine central effect is mediated via non-selective (AO and selective (A;*) adenosine receptors antagonism.
Variability in caffeine response had been frequently noticed in AOP, suggesting underlying genetic predisposition.
Aim of the study: We evaluated the role of adenosine receptor Ax [ADORAJ and adenosine receptor A^ [ADORA2a] gene polymorphisms in the variability of caffeine response among Egyptian preemies with AOP.
Patient and methods: In this case-control study, 43 preterm neonates with AOP were eligible as cases and 43 preterm babies free from apnea were taken as controls.
Preterm neonates with AOP were further divided ac- cording to response to caffeine treatment into caffeine responder (n = 18) and caffeine non-responders (n = 25).
ADORAj [716 T > G] and ADORA2a [1976C > T] gene polymorphisms were genotyped by mean of PCR-based RFLP-assay.
Results: There were significant increase in frequency distribution of ADORA2a [1976C > T] CT (62.7% vs 23.3%), TT (14% vs 4.7%) genotypes and T allele (34.3% vs 16.3%) in cases compared to controls with sig- nificant increased risk of AOP development with OR (95%CI); P-value of 8.37(3.03-23.1), P = 0.000; 9.3(1.61-53.61), P = 0.005 and 4.27(2.09-8.70), P = 0.000 respectively.
Further, caffeine non-responders were associated with significant increase frequency of ADORA2a CT (80% vs 38.9%) and TT (16% vs 11.1%) geno-types and T allele (56% vs 30.6%) with OR (95%CI) and P-value of 21.38 (2.31-197.8), P = 0.001; 18 (1.24-260.9); P = 0.005 and 2.89(1.17-7.13), P = 0.019 respectively, when compared to caffeine responders.
Patients with AOP who had ADORA2a CT and TT genotypes were associated with significant increase in duration of hospital stay and poor outcome.
Genotype distribution frequency of studied polymorphisms did not deviate from Hardy Weinberg (HW) equilibrium among controls.
Conclusion: ADORA2a [1976C > T] polymorphism has a significant role in AOP development and variation in caffeine response among preterm babies.
American Psychological Association (APA)
Mukhtar, Wisam A.& Fawzi, Amal& Allam, Rim M.& Zaydan, Nahlah& Hamid, Muna S.. 2018. Association between adenosine receptor gene polymorphism and response to caffeine citrate treatment in apnea of prematurity : an Egyptian single-center study. Egyptian Pediatric Association Gazette،Vol. 66, no. 4, pp.115-120.
https://search.emarefa.net/detail/BIM-855556
Modern Language Association (MLA)
Mukhtar, Wisam A.…[et al.]. Association between adenosine receptor gene polymorphism and response to caffeine citrate treatment in apnea of prematurity : an Egyptian single-center study. Egyptian Pediatric Association Gazette Vol. 66, no. 4 (Dec. 2018), pp.115-120.
https://search.emarefa.net/detail/BIM-855556
American Medical Association (AMA)
Mukhtar, Wisam A.& Fawzi, Amal& Allam, Rim M.& Zaydan, Nahlah& Hamid, Muna S.. Association between adenosine receptor gene polymorphism and response to caffeine citrate treatment in apnea of prematurity : an Egyptian single-center study. Egyptian Pediatric Association Gazette. 2018. Vol. 66, no. 4, pp.115-120.
https://search.emarefa.net/detail/BIM-855556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 119-120
Record ID
BIM-855556