Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma
Joint Authors
al-Ubaydi, Salim Rashid
al-Faysal, Abd al-Husayn Muwayt
al-Dirisawi, Mahdi Sabir
Source
Iraqi Journal of Biotechnology
Issue
Vol. 17, Issue 2 (30 Sep. 2018), pp.82-90, 9 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2018-09-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
The objective of this study was to investigate the role of SOX4 gene in progression of endometrial hyperplasia to endometrial adenocarcinoma .A total of 14 Iraqi patients with abnormal uterine bleeding followed by hysterectomy.
Histological findings recorded 36 cases with endometrial hyperplasia and 5 endometrium adenocarcenoma.
Cases collected during the period from February 2017 to October 2017.
Curettage techniques were used to obtain a ten samples as healthy control group.
All cases were obtained from Al-Zahra Teaching Hospital in Wasit Province .
Endometrial hyperplasia subjects distributed according to age, the highest percentage ranged (40-50)years recorded (58.33%).
To evaluate the SOX4 gene expression, total RNAs were extracted with TRIzol from each sample then directly converted to cDNA.
RT-PCR technique was used to estimate the SOX4 gene expression and (GAPDH gene used as a reference gene).
The results revealed that there was a highly significant increase (p<0.01) in SOX4 gene expression in endometrium adenocarcenoma (9.24±0.52) followed by endometrial hyperplasia (6.14±0.17) when compared to the healthy control group (1±0.00).In conclusion, endometrial hyperplasia can be a precursor of endometrium adenocarcenoma when the SOX4 gene expression elevated gradually.
American Psychological Association (APA)
al-Dirisawi, Mahdi Sabir& al-Faysal, Abd al-Husayn Muwayt& al-Ubaydi, Salim Rashid. 2018. Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma. Iraqi Journal of Biotechnology،Vol. 17, no. 2, pp.82-90.
https://search.emarefa.net/detail/BIM-900342
Modern Language Association (MLA)
al-Faysal, Abd al-Husayn Muwayt…[et al.]. Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma. Iraqi Journal of Biotechnology Vol. 17, no. 2 (Sep. 2018), pp.82-90.
https://search.emarefa.net/detail/BIM-900342
American Medical Association (AMA)
al-Dirisawi, Mahdi Sabir& al-Faysal, Abd al-Husayn Muwayt& al-Ubaydi, Salim Rashid. Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma. Iraqi Journal of Biotechnology. 2018. Vol. 17, no. 2, pp.82-90.
https://search.emarefa.net/detail/BIM-900342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 88-90
Record ID
BIM-900342