Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks

Joint Authors

He, Feng
Wang, Xiying
Ren, Huimin
Sun, Laiguang
Yuan, Jian Min

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2000-2005, 6 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Topic

Diseases
Medicine

Topics

Abstract EN

Objective: To investigate the association between DD, ID and II genotypes of ACE gene and carotid stenosis, and to construct a network of ACE-related genes regulating carotid stenosis. Approaches: Meta-analysis was used to study the association between three genotypes DD, ID and II of carotid stenosis susceptibility gene ACE; functional annotation of ACE gene was conducted by GO analysis; and a network of ACE-related genes that regulate the mechanisms of carotid stenosis was established. Results: Meta-analysis showed that DD and II genotypes of ACE gene were associated with carotid stenosis. GO analysis showed that the main biological processes involved in ACE include: the process of transforming angiotensinogen into mature angiotensin; angiotensin’s mediation of the brain’s response to alcohol consumption and thirst control; any chemical reaction involving the regulation of angiotensin; and the process of catalyzing the release of a C-terminal dipeptide from a polypeptide chain. A network of ACE gene regulation of carotid stenosis was constructed in combination with KEGG analysis. Conclusion: The ACE gene is a susceptibility gene for carotid stenosis. Through the functional annotation and pathway analysis of ACE gene, an ACE gene-involved carotid stenosis regulatory mechanisms network was constructed.

American Psychological Association (APA)

He, Feng& Wang, Xiying& Ren, Huimin& Yuan, Jian Min& Sun, Laiguang. 2019. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182

Modern Language Association (MLA)

He, Feng…[et al.]. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182

American Medical Association (AMA)

He, Feng& Wang, Xiying& Ren, Huimin& Yuan, Jian Min& Sun, Laiguang. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2005

Record ID

BIM-910182