Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model

Joint Authors

Fan, Xiaowu
Li, Fan
Deng, Yu
Wu, Xiaowei

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2037-2042, 6 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Topic

Diseases
Medicine

Topics

Abstract EN

The purpose of this study was to explore the internal mechanism of lung cancer under the action of caspase recruitment domain-containing protein 9 (CARD9) and immunosuppressive cells myeloid-derived suppressor cells (MDSCs) in the Lewis lung cancer mice model. In this research, mice were selected as research objects, and the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was studied by experimental methods such as mRNA expression level, HE staining of tumor cells, and electron microscopy. The results showed that CARD9 regulated lung cancer by controlling the working state of immunosuppressive cells MDSCs and its downstream product indoleamine 2, 3-dioxygenase (IDO). The study confirmed the tumor regulatory mechanism of CARD9-MDSCs-NF-KB-IDO in MDSCs under tumor environment. In summary, the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was to achieve the goal of tumor control through the control of downstream product IDO. There are still some shortcomings in the research process, but the research results still provide some guidance for future research. Therefore, it is a research topic with practical significance.

American Psychological Association (APA)

Wu, Xiaowei& Li, Fan& Deng, Yu& Fan, Xiaowu. 2019. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216

Modern Language Association (MLA)

Wu, Xiaowei…[et al.]. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216

American Medical Association (AMA)

Wu, Xiaowei& Li, Fan& Deng, Yu& Fan, Xiaowu. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2041-2042

Record ID

BIM-910216