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Objective: The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model. Methods: Kunming mice were randomized into 5 groups randomly (n = 12/group; half male and female), and given 0.9%Nacl (10 mL/Kg Serving as blank control group)orally, 0.6 g/kg rhodiola capsule (Serving as positive group) and Tremella extract at doses of high (3.0 g/kg), middle (1.5 g/kg) and low (0.5 g/kg) once a day for 14 days. At the end of drug intragastric gavage, following endurance running test, rotating rod test, normobarie hypoxia test and sodium nitrite poisoning test were performed. Result: 14-day Tremella extract administration fails to influence mouse horizontal and vertical movement indicating little neurotoxicity at chosen doses. Through rotating rod, forced running test, the anti-fatigue activity of Tremella extract was demonstrated. Via normobarie hypoxia test, sodium nitrite poisoning test, Tremella extract was confirmed to possess anti-hypoxia effect. Tremella extract treatment significantly enhanced the liver levels of superoxide dismutase (SOD), and glutathione peroxidase (GSHPx), increased the expressions of ATP and hepatic glycogen, muscle glycogen in tissue. Conclusion: We conclude that Tremella extract efficiently enhances mouse fatigue endurance and antihypoxia capability partly through energy reserves and antioxidant enzyme activity.
American Psychological Association (APA)
Yang, Dongsheng& Lian, Junhui& Wang, Lanying& Liu, Xiaomei& Wang, Yanzhen& Zhang, Xiaoming…[et al.]. 2019. The anti-fatigue and anti-anoxia effects of Tremella extract. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2052-2056.
Modern Language Association (MLA)
Yang, Dongsheng…[et al.]. The anti-fatigue and anti-anoxia effects of Tremella extract. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2052-2056.
American Medical Association (AMA)
Yang, Dongsheng& Lian, Junhui& Wang, Lanying& Liu, Xiaomei& Wang, Yanzhen& Zhang, Xiaoming…[et al.]. The anti-fatigue and anti-anoxia effects of Tremella extract. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2052-2056.
Includes bibliographical references : p. 2056