Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS
Joint Authors
Li, Genxia
Gao, Wanli
Xu, Yajuan
Xie, Mingkun
Tang, Suhua
Yin, Pan
Guo, Shuhua
Chu, Shuhui
Sultana, Shaima
Cui, Shihong
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 8 (31 Dec. 2019), pp.2057-2063, 7 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objective: Through metabolomics method, the objective of the paper is to differentially screen serum metabolites of GDM patients and healthy pregnant women, to explore potential biomarkers of GDM and analyze related pathways, and to explain the potential mechanism and biological significance of GDM.
Methods: The serum samples from 30 GDM patients and 30 healthy pregnant women were selected to conduct non-targeted metabolomics study by liquid chromatography-mass spectrometry.
The differential metabolites between the two groups were searched and the metabolic pathway was analyzed by KEGG database.
Results: Multivariate statistical analysis found that serum metabolism in GDM patients was different significantly from healthy pregnant women, 36 differential metabolites and corresponding metabolic pathways were identified in serum, which involved several metabolic ways like, fatty acid metabolism, butyric acid metabolism, bile secretion, and amino acid metabolism.
Conclusion: The discovery of these biomarkers provided a new theoretical basis and experimental basis for further study of the early diagnosis and pathogenesis of GDM.
At the same time, LC-MS-based serum metabolomics methods also showed great application values in disease diagnosis and mechanism research
American Psychological Association (APA)
Gao, Wanli& Xu, Yajuan& Xie, Mingkun& Tang, Suhua& Yin, Pan& Li, Genxia…[et al.]. 2019. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398
Modern Language Association (MLA)
Li, Genxia…[et al.]. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398
American Medical Association (AMA)
Gao, Wanli& Xu, Yajuan& Xie, Mingkun& Tang, Suhua& Yin, Pan& Li, Genxia…[et al.]. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2063
Record ID
BIM-910398