Influence of bone mineral density in circulating adipokines among postmenopausal Arab women

Joint Authors

Yaqut, Subhi M.
Ansari, Muhammad Ghouse Ahmad
Husayn, Sayyid Danish
Wani, Qaysar Ahmad
al-Disi, Dara
Reginster, Jean Yves
al-Daghri, Nasir M.
al-Aqil, Majid S.

Source

Saudi Journal of Biological Sciences

Issue

Vol. 27, Issue 1 (31 Jan. 2020), pp.374-379, 6 p.

Publisher

Saudi Biological Society

Publication Date

2020-01-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Topic

Biology

Topics

Abstract EN

Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall −0.34, p < 0.01; low BMD group −0.34, p < 0.01). In multiple regression, adiponectin (−0.29 ± 0.06, p < 0.00) and resistin (−0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (−0.05 ± 0.04, p < 0.224) whereas adiponectin remained (−0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.

American Psychological Association (APA)

Ansari, Muhammad Ghouse Ahmad& Husayn, Sayyid Danish& Wani, Qaysar Ahmad& Yaqut, Subhi M.& al-Disi, Dara& al-Aqil, Majid S.…[et al.]. 2020. Influence of bone mineral density in circulating adipokines among postmenopausal Arab women. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.374-379.
https://search.emarefa.net/detail/BIM-920685

Modern Language Association (MLA)

al-Aqil, Majid S.…[et al.]. Influence of bone mineral density in circulating adipokines among postmenopausal Arab women. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.374-379.
https://search.emarefa.net/detail/BIM-920685

American Medical Association (AMA)

Ansari, Muhammad Ghouse Ahmad& Husayn, Sayyid Danish& Wani, Qaysar Ahmad& Yaqut, Subhi M.& al-Disi, Dara& al-Aqil, Majid S.…[et al.]. Influence of bone mineral density in circulating adipokines among postmenopausal Arab women. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.374-379.
https://search.emarefa.net/detail/BIM-920685

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 378-379

Record ID

BIM-920685