Evaluation of sex hormone levels in benign prostatic hyperplasia patients treated with 5 alpha-reductase inhibitor (Finasteride)‎ in Amara city Iraq

Other Title(s)

تقييم مستوى الهرمونات الجنسية في مرضى تضخم البروستات الحميد المعالجين بمثبط 5-الفا ريدكتيز (الفيناسترايد)‎ في مدينه العمارة العراق

Joint Authors

Khalifah, Ahmad Abbud
Muhammad, Mukhtar Khamis
Hashim, Nidal Abd Allah

Source

Baghdad Science Journal

Issue

Vol. 17, Issue 1 (31 Mar. 2020), pp.1-8, 8 p.

Publisher

University of Baghdad College of Science for Women

Publication Date

2020-03-31

Country of Publication

Iraq

No. of Pages

8

Main Subjects

Medicine

Topics

Abstract EN

The present study aimed to determine the serum sex hormone levels among Benign Prostatic Hyperplasia (BPH) patients before and after 3 months of oral administration of 5-α reductase inhibitor(finasteride).

Forty BPH patients and 40 healthy men from Amara city were involved in this study, their ages were between 40-59 year.

They were all subjected to direct estimation of hormones by MinVidas method including Testosterone (T), Estradiol (E2), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL), and Dihydrotestosterone (DHT) before and after 3 months of treatment with 5α-reductase inhibitor (finasteride) (the healthy individuals didn’t take finasteride).The results showed that T level was significantly lower (P<0.05) in pre-treated compared to the post-treated patients and control group, whereas no significant difference was observed between the two latter groups.

Levels of E2 - and DHT were significantly lower (P<0.01) in post-treated compared to the pre-treated patients with no significant difference with control group, while they were significantly higher (P<0.01) in pre-treated patients compared to control group.

FSH and LH levels showed no significant differences in the pre-treated in comparison with post-treated and control groups.

PRL levels insignificantly higher in pre-treated in comparison with post-treated patients, while significantly higher (P<0.05) in comparison with control group, with the later showing a significant lower (P<0.05) in comparison with post-treated patients.

It is concluded that 5α-reductase inhibitor (finasteride) plays a role in decreasing levels of DHT and E2 which have vital roles in enlargement of prostate.

American Psychological Association (APA)

Hashim, Nidal Abd Allah& Khalifah, Ahmad Abbud& Muhammad, Mukhtar Khamis. 2020. Evaluation of sex hormone levels in benign prostatic hyperplasia patients treated with 5 alpha-reductase inhibitor (Finasteride) in Amara city Iraq. Baghdad Science Journal،Vol. 17, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-935347

Modern Language Association (MLA)

Hashim, Nidal Abd Allah…[et al.]. Evaluation of sex hormone levels in benign prostatic hyperplasia patients treated with 5 alpha-reductase inhibitor (Finasteride) in Amara city Iraq. Baghdad Science Journal Vol. 17, no. 1 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-935347

American Medical Association (AMA)

Hashim, Nidal Abd Allah& Khalifah, Ahmad Abbud& Muhammad, Mukhtar Khamis. Evaluation of sex hormone levels in benign prostatic hyperplasia patients treated with 5 alpha-reductase inhibitor (Finasteride) in Amara city Iraq. Baghdad Science Journal. 2020. Vol. 17, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-935347

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 6-7

Record ID

BIM-935347