Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study
Other Title(s)
التأثير الموضعي للحقن العضلي لعقاري الميلوكسيكام و الدكلوفيناك : دراسة تجريبية مقارنه و نسيجية
Joint Authors
Hamdi, Umar Riyad
Ayyub, Ashraf Abd al-Rahim
Jirjis, Muhammad Tayyib Tahir
Qasim, Ahmad Hisham
Source
Annals of the College of Medicine Mosul
Issue
Vol. 41, Issue 2 (30 Jun. 2019), pp.163-169, 7 p.
Publisher
University of Mosul College of Medicine-Mosul
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Objectives: To compare the local effect of therapeutic doses of meloxicam and diclofenac on the muscle of rats at different periods by intramuscular injection.
Materials and methods: Thirty six adult albino rats were divided equally into 6 groups.
The 1st and 2nd groups were injected intramuscularly with normal saline for 2 and 4 weeks respectively, the 3rd and 4th groups were injected intramuscularly with meloxicam for 2 and 4 weeks respectively, the last 2 groups were injected intramuscularly with diclofenac sodium also for 2 and 4 weeks respectively.
The drugs were injected into the quadriceps femoris muscle of the right femur once each day till the end of the period stated.
The specimens were histologically processed, stained with hematoxylin and eosin and examined with light microscope.
Results: No changes were seen in quadriceps femoris muscles of groups 1, 2, 3 and 4, whereas group 5 showed congested blood vessels within normal muscle tissue.
In Group 6 mononuclear inflammatory cells infiltration, vascular congestion, fibrosis, degenerative changes and muscle tissue necrosis were seen.
Conclusion: Meloxicam is safer than diclofenac sodium on muscular tissue after a long-term daily intramuscular injection.
American Psychological Association (APA)
Qasim, Ahmad Hisham& Hamdi, Umar Riyad& Ayyub, Ashraf Abd al-Rahim& Jirjis, Muhammad Tayyib Tahir. 2019. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul،Vol. 41, no. 2, pp.163-169.
https://search.emarefa.net/detail/BIM-946656
Modern Language Association (MLA)
Qasim, Ahmad Hisham…[et al.]. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul Vol. 41, no. 2 (Jun. 2019), pp.163-169.
https://search.emarefa.net/detail/BIM-946656
American Medical Association (AMA)
Qasim, Ahmad Hisham& Hamdi, Umar Riyad& Ayyub, Ashraf Abd al-Rahim& Jirjis, Muhammad Tayyib Tahir. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul. 2019. Vol. 41, no. 2, pp.163-169.
https://search.emarefa.net/detail/BIM-946656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 167-169
Record ID
BIM-946656