Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study

Other Title(s)

التأثير الموضعي للحقن العضلي لعقاري الميلوكسيكام و الدكلوفيناك : دراسة تجريبية مقارنه و نسيجية

Joint Authors

Hamdi, Umar Riyad
Ayyub, Ashraf Abd al-Rahim
Jirjis, Muhammad Tayyib Tahir
Qasim, Ahmad Hisham

Source

Annals of the College of Medicine Mosul

Issue

Vol. 41, Issue 2 (30 Jun. 2019), pp.163-169, 7 p.

Publisher

University of Mosul College of Medicine-Mosul

Publication Date

2019-06-30

Country of Publication

Iraq

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Objectives: To compare the local effect of therapeutic doses of meloxicam and diclofenac on the muscle of rats at different periods by intramuscular injection.

Materials and methods: Thirty six adult albino rats were divided equally into 6 groups.

The 1st and 2nd groups were injected intramuscularly with normal saline for 2 and 4 weeks respectively, the 3rd and 4th groups were injected intramuscularly with meloxicam for 2 and 4 weeks respectively, the last 2 groups were injected intramuscularly with diclofenac sodium also for 2 and 4 weeks respectively.

The drugs were injected into the quadriceps femoris muscle of the right femur once each day till the end of the period stated.

The specimens were histologically processed, stained with hematoxylin and eosin and examined with light microscope.

Results: No changes were seen in quadriceps femoris muscles of groups 1, 2, 3 and 4, whereas group 5 showed congested blood vessels within normal muscle tissue.

In Group 6 mononuclear inflammatory cells infiltration, vascular congestion, fibrosis, degenerative changes and muscle tissue necrosis were seen.

Conclusion: Meloxicam is safer than diclofenac sodium on muscular tissue after a long-term daily intramuscular injection.

American Psychological Association (APA)

Qasim, Ahmad Hisham& Hamdi, Umar Riyad& Ayyub, Ashraf Abd al-Rahim& Jirjis, Muhammad Tayyib Tahir. 2019. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul،Vol. 41, no. 2, pp.163-169.
https://search.emarefa.net/detail/BIM-946656

Modern Language Association (MLA)

Qasim, Ahmad Hisham…[et al.]. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul Vol. 41, no. 2 (Jun. 2019), pp.163-169.
https://search.emarefa.net/detail/BIM-946656

American Medical Association (AMA)

Qasim, Ahmad Hisham& Hamdi, Umar Riyad& Ayyub, Ashraf Abd al-Rahim& Jirjis, Muhammad Tayyib Tahir. Local effect of intramuscular injection of meloxicam and diclofenac : an experimental, comparative and histological study. Annals of the College of Medicine Mosul. 2019. Vol. 41, no. 2, pp.163-169.
https://search.emarefa.net/detail/BIM-946656

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 167-169

Record ID

BIM-946656