Association of polymorphisms in slc11a1 gene with autoimmunity caused by Mycobacterium avium subspecies paratuberculosis (MAP) in cattle
Other Title(s)
ارتباط تعدد اشكال الجينSLC11A1 بالمناعة الذاتية الناتجة من جرثومة Mycobacterium avium subspecies paratyberculosis في الأبقار
Joint Authors
Jabr, Kawthar Kazim
Abd Allah, Fawziyah Ali
al-Salam, Rasha Mundhir Uthman
Source
Basrah Journal of Veterinary Research
Issue
Vol. 18, Issue 1 (30 Jun. 2019), pp.263-277, 15 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Abstract EN
Johne's disease is one of the main causes of economic losses in ruminants and a major health hazard in the developed and developing developed countries.In this study, PCR detection of insertion sequences IS900 of MAP in the buffy coat of cows (n = 81), of this 29 (35.8%) cow showed positive results.
By Restriction fragment length polymorphism (PCR-RFLP),two single nucleotide polymorphisms (SNPs) of SLC11A1 gene were tested for finding their association with susceptibility to bovine Johens disease in Iraqi cattle.
A total of 50 cows were tested, theirresult revealedthat at rs109453173 locus twoelectromorph‘CC’ (374 bp) and ‘CG’ (374, 293 and 81 bp).The rs109915208 locus also showed two electromorph, ‘TT (344bp) and ‘CT’ (344, 215 and 129 bp) .
The differences in the electromorph between IS900 positive and negative cows were found to be statistically significant (p = 0.0031).
No significant difference in these electromorph at SNP locus rs109915208 between IS900 positive and negative cows.
Out of two SNPs from SLC11A1 gene, rs109453173 had a significant association with the susceptibility to Johne's disease.
The CC’ electromorph observed at rs109453173 locus showed a significant association with the susceptibility to bovine paratuberculosis in cows.
The OR of ‘CC’ in‘IS900 positive versusIS900 negative cattle was7.8750, suggesting that cows having ‘CC’ electromorph were susceptible to Johne's disease compared to ‘CG’ electromorph .
American Psychological Association (APA)
Jabr, Kawthar Kazim& Abd Allah, Fawziyah Ali& al-Salam, Rasha Mundhir Uthman. 2019. Association of polymorphisms in slc11a1 gene with autoimmunity caused by Mycobacterium avium subspecies paratuberculosis (MAP) in cattle. Basrah Journal of Veterinary Research،Vol. 18, no. 1, pp.263-277.
https://search.emarefa.net/detail/BIM-946674
Modern Language Association (MLA)
Jabr, Kawthar Kazim…[et al.]. Association of polymorphisms in slc11a1 gene with autoimmunity caused by Mycobacterium avium subspecies paratuberculosis (MAP) in cattle. Basrah Journal of Veterinary Research Vol. 18, no. 1 (2019), pp.263-277.
https://search.emarefa.net/detail/BIM-946674
American Medical Association (AMA)
Jabr, Kawthar Kazim& Abd Allah, Fawziyah Ali& al-Salam, Rasha Mundhir Uthman. Association of polymorphisms in slc11a1 gene with autoimmunity caused by Mycobacterium avium subspecies paratuberculosis (MAP) in cattle. Basrah Journal of Veterinary Research. 2019. Vol. 18, no. 1, pp.263-277.
https://search.emarefa.net/detail/BIM-946674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 274-277
Record ID
BIM-946674