Protective effect of placental mesenchymal stem cells on histological changes of pancreas experimentally induced by alloxane in mice

Other Title(s)

الدور الوقائي للخلايا الجذعية اللحمية للمشيمة على التغيرات النسجية للبنكرياس المستحدثة تجريبيا باستخدام الألوكسان في الفئران

Joint Authors

al-Sabawi, Rasha Aziz Muhammad
Jumah, Hamad Jandari
Ismail, Hana Khalil

Source

Iraqi Journal of Veterinary Sciences

Issue

Vol. 34, Issue 1 (30 Jun. 2020), pp.1-8, 8 p.

Publisher

University of Mosul College of Veterinary Medicine

Publication Date

2020-06-30

Country of Publication

Iraq

No. of Pages

8

Main Subjects

Veterinary Medicine

Abstract EN

In an attempt to find a treatment for diabetes by Placental mesenchymal stem cells, we induced diabetes in albino mice by injected them with the diabetic agent Alloxan intra peritoneal cavity dose 70 mg / kg of body weight for the group 1 and 2, then injection of the diabetic mice with Placental mesenchymal stem cells in the peritoneal cavity for the group 2 then the glucose levels in the blood of these mice were measured by using a GLUCOTREND 2, while group 3 was control injected with normal saline only.

Pancreas tissue where tested by studying histopathological effect of Alloxan, the endocrine pancreas histologically showed decreased in the size and number of Langerhans islets with vacuolar degeneration and necrosis of almost all cells in the atrophied islets.

Also, there was congestion of blood vessels in the interlobular space and there was distortion of exocrine pancreas.

There was vacuolar degeneration and necrosis of the epithelial cells of the acini, also there was atrophy of acini which lead to edema and dilatation of interacini space.

Moreover, there was thickening in the wall of blood vessels, and there was thrombus in some blood vessels.

In addition to the infiltration of inflammatory cells in the interlobular septa.

Compared with the section of pancreas of control group showed the normal structure of islets notice the normal cells shape surrounding by exocrine pancreas.

Then the pancreas studied after injection of Placental mesenchymal stem cells, while there was regeneration of islets and acini which seem to be normal comparing with control group, there was improvement of normal histological appearance of mice treated with alloxan and then injected with placental mesenchymal stem cells.

The results of the diabetic mice which treated with placental mesenchymal stem cells demonstrated present of significant differences (P≤0.05).

Our conclusion of this study revealed that placental mesenchymal stem cells have a protective role against the histological changes of pancreas induced by alloxan.

American Psychological Association (APA)

Ismail, Hana Khalil& al-Sabawi, Rasha Aziz Muhammad& Jumah, Hamad Jandari. 2020. Protective effect of placental mesenchymal stem cells on histological changes of pancreas experimentally induced by alloxane in mice. Iraqi Journal of Veterinary Sciences،Vol. 34, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-948779

Modern Language Association (MLA)

Ismail, Hana Khalil…[et al.]. Protective effect of placental mesenchymal stem cells on histological changes of pancreas experimentally induced by alloxane in mice. Iraqi Journal of Veterinary Sciences Vol. 34, no. 1 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-948779

American Medical Association (AMA)

Ismail, Hana Khalil& al-Sabawi, Rasha Aziz Muhammad& Jumah, Hamad Jandari. Protective effect of placental mesenchymal stem cells on histological changes of pancreas experimentally induced by alloxane in mice. Iraqi Journal of Veterinary Sciences. 2020. Vol. 34, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-948779

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 8

Record ID

BIM-948779