Influence of chitosan on hematological and histopathological changes in mice infected with Brucella melitensis immunized with Rev-1 vaccine
Other Title(s)
تأثير الكيتوسان على التغيرات في الصفات الدموية و النسيجية في الفئران الملقحة بلقاح Rev-1 و المصابة بالبروسيلا المالطية
Joint Authors
al-Khafaji, Muna Abd al-Sahib Jalil
al-Sultani, Hamzah Hadi
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 34, Issue 1 (30 Jun. 2020), pp.23-29, 7 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2020-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
This study aimed to assess the changes of blood cells constitutions and study the histopathological sections of liver and spleen in dual sexes mice infected with brucella melitensis and the role of chitosan supplement with and without Rev-1 vaccine in enhancing the inflammatory proses, two experiments were undertaken on 100 albino mice, aged 8-10 weeks for 60 days, first experiment done on 50 males and second one done on 50 females.
Results of hematological analysis showed that there are significant increase at P<0.001 of white blood cells count WBC (×103), red blood cells count RBC (× 106), hematocrit (HCT), mean corpuscular value (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), lymphocyte (LY%), granulocyte (GR) and lymphocytes m/mm3 (LYM) in males treated groups comparing with females, the highest values were in immunized infected mice with chitosan diet supplement compared to infected animals.
The histopathological lesions recorded there is presence of chronic inflammatory reaction characterized by mononuclear cell infiltration with presence of granulomatous lesion in the liver of immunized animals, presence of mild to moderate lesions characterized by hyperplasia of lymphoid tissue in spleen and small granulomatous lesions in liver of immunized animals fed diet with chitosan supplement.
American Psychological Association (APA)
al-Khafaji, Muna Abd al-Sahib Jalil& al-Sultani, Hamzah Hadi. 2020. Influence of chitosan on hematological and histopathological changes in mice infected with Brucella melitensis immunized with Rev-1 vaccine. Iraqi Journal of Veterinary Sciences،Vol. 34, no. 1, pp.23-29.
https://search.emarefa.net/detail/BIM-948782
Modern Language Association (MLA)
al-Khafaji, Muna Abd al-Sahib Jalil& al-Sultani, Hamzah Hadi. Influence of chitosan on hematological and histopathological changes in mice infected with Brucella melitensis immunized with Rev-1 vaccine. Iraqi Journal of Veterinary Sciences Vol. 34, no. 1 (2020), pp.23-29.
https://search.emarefa.net/detail/BIM-948782
American Medical Association (AMA)
al-Khafaji, Muna Abd al-Sahib Jalil& al-Sultani, Hamzah Hadi. Influence of chitosan on hematological and histopathological changes in mice infected with Brucella melitensis immunized with Rev-1 vaccine. Iraqi Journal of Veterinary Sciences. 2020. Vol. 34, no. 1, pp.23-29.
https://search.emarefa.net/detail/BIM-948782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-29
Record ID
BIM-948782