Histopathological and functional changes in kidney of male rabbits infected with Pseudomonas aeruginosa

Abstract EN

This study was designed to clarify the histopathological and functional changes in kidney caused by bacterial DNA released upon bacterial autolysis or killed by antibiotic.12 males of rabbits were divided into two groups, each group included 6 rabbits.

First group[G1]was considered as control injected with phosphate buffered saline[PBS],second group[G2]was injected into the urinary bladder via inoculums[50µl] were injected by the aid of catheter[0.6mm in diameter] both groups feed ad Libitum with conventional diet.

The main histopathological changes in kidneys were infiltrated inflammatory cells, macrophages and neutrophils adjacent blood vessels, damage of glomerular and massive necrosis in the tubules.

That resulted showed changes in kidney function such us significant increase (P<0.05) in plasma levels of creatinine and urea.