Immunocytochemical assessment of FKBP51 and glucocorticoid receptor localization in asthmatic patients
Other Title(s)
تقييم كيمومناعي لتوزيع بروتين FKBP51 و مستلم القشرانيات السكرية في مرضى الربو
Joint Authors
Yinzil, Jabbar Hamid
al-Saffar, Sura Fuad Abd al-Amir
Source
Issue
Vol. 60, Issue 12 (31 Dec. 2019), pp.2609-2617, 9 p.
Publisher
University of Baghdad College of Science
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Asthma is a chronic inflammatory disease affecting 5% of the world population.
FKBP51 is an important immunophilin modular protein of the glucocorticoid receptor (GC).
The aim of the present study was to evaluate the levels and immunocytochemical distribution of FKBP51 and GR in lymphocyte cells of asthmatic patients, by use of immunocytochemistry method, and to assesslevels ofstress hormones (cortisol and ACTH) by radioimmuniassay (RIA).
The results showed significantly increased nuclear localization and decreasedcytoplasmic distribution of FKBP51, while they showed a significant increase in nuclear localization and a non-significant decrease in cytoplasmic distribution of GRin asthmatic patients(P<0.05).
Cortisol and ACTH levels were also measured and showedinsignificant increases(P<0.05)in steroid treated (338.85 ±139.5 mMol/L, 35.05±3.77 ng/ml, respectively)and non steroid treated asthmatics(280.5 ± 74.6 mMol/L, 32.0±6.43 ng/ml, respectively)as compared with the control group (234.33±29.13 mMol/L, 29.0±7.02 ng/ml, respectively).
American Psychological Association (APA)
al-Saffar, Sura Fuad Abd al-Amir& Yinzil, Jabbar Hamid. 2019. Immunocytochemical assessment of FKBP51 and glucocorticoid receptor localization in asthmatic patients. Iraqi Journal of Science،Vol. 60, no. 12, pp.2609-2617.
https://search.emarefa.net/detail/BIM-969551
Modern Language Association (MLA)
al-Saffar, Sura Fuad Abd al-Amir& Yinzil, Jabbar Hamid. Immunocytochemical assessment of FKBP51 and glucocorticoid receptor localization in asthmatic patients. Iraqi Journal of Science Vol. 60, no. 12 (2019), pp.2609-2617.
https://search.emarefa.net/detail/BIM-969551
American Medical Association (AMA)
al-Saffar, Sura Fuad Abd al-Amir& Yinzil, Jabbar Hamid. Immunocytochemical assessment of FKBP51 and glucocorticoid receptor localization in asthmatic patients. Iraqi Journal of Science. 2019. Vol. 60, no. 12, pp.2609-2617.
https://search.emarefa.net/detail/BIM-969551
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-969551