Diagnostic value of estimating the ratio of serum free triiodothyronine to free thyroxine in differenti-ating Graves' disease from thyroiditis

Joint Authors

Ibrahim, Nismah A.
Hammam, Ahmad M.

Source

Suez Canal University Medical Journal

Issue

Vol. 23, Issue 2 (31 Dec. 2020), pp.135-142, 8 p.

Publisher

Suez Canal University Faculty of Medicine

Publication Date

2020-12-31

Country of Publication

Egypt

No. of Pages

8

Main Topic

Diseases

Topics

Abstract EN

Background : As the treatment approaches of Graves’ disease (GD) and thyroiditis are different, the differential diagnosis is essential.

Aim: To assess the diagnostic value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio for differentiation between GD and destructive thyroiditis.

Subjects and Methods: The present study was conducted on 100 newly diagnosed thyrotoxicosis patients; 61 with thyroiditis (group 1) and 39 with GD (group 2) and 20 healthy, age-matched subjects representing a control group (Group 3).

All participants underwent medical history taking and clinical examination, serum levels of thyroid-stimulating hormone (TSH), FT3, and FT4 were measured, Technetium 99m thyroid Scan was done to all recruited patients.

Results: The present results recorded significant increases in FT3, FT4, and decreases in TSH levels in Graves’ disease group than in the thyroiditis group.

There was a statistically significant difference between the study groups regarding FT3/FT4 ratio, which was lower in thyroiditis group than in Graves’ disease group (0.21± 0.03 in group 1 vs 0.35±0.18 in group 2, p-value < 0.01), while there was no significant difference between thyroiditis group and the control group.

The FT3/FT4 ratio showed a predictive value, with an area under the ROC curve (AUC) of 0.936 (95%CI, 0.876-0.995) for Graves' disease vs.

thyroiditis (p < 0.001).

Based on the cutoff value of this ratio of more than 0.269 offered a sensitivity of 89.7% and specificity of 91.8%.

Conclusion: The results of the present study demonstrated that free thyroid hormones and the FT3/FT4 ratio are useful to differentiate Graves’ disease from destructive thyroiditis.

American Psychological Association (APA)

Ibrahim, Nismah A.& Hammam, Ahmad M.. 2020. Diagnostic value of estimating the ratio of serum free triiodothyronine to free thyroxine in differenti-ating Graves' disease from thyroiditis. Suez Canal University Medical Journal،Vol. 23, no. 2, pp.135-142.
https://search.emarefa.net/detail/BIM-980523

Modern Language Association (MLA)

Ibrahim, Nismah A.& Hammam, Ahmad M.. Diagnostic value of estimating the ratio of serum free triiodothyronine to free thyroxine in differenti-ating Graves' disease from thyroiditis. Suez Canal University Medical Journal Vol. 23, no. 2 (2020), pp.135-142.
https://search.emarefa.net/detail/BIM-980523

American Medical Association (AMA)

Ibrahim, Nismah A.& Hammam, Ahmad M.. Diagnostic value of estimating the ratio of serum free triiodothyronine to free thyroxine in differenti-ating Graves' disease from thyroiditis. Suez Canal University Medical Journal. 2020. Vol. 23, no. 2, pp.135-142.
https://search.emarefa.net/detail/BIM-980523

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 141-142

Record ID

BIM-980523