Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders
Joint Authors
Geboes, Karel
Abu El-Asrar, Ahmed M.
Nawaz, Mohd Imtiaz
Kangave, Dustan
Siddiquei, Mohammad Mairaj
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to determine the levels of the angiogenic and fibrogenic factors osteopontin (OPN), high-mobility group box-1 (HMGB1), and connective tissue growth factor (CTGF) and the antiangiogenic and antifibrogenic pigment epithelium-derived factor (PEDF) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and rhegmatogenous retinal detachment with no PVR (RD).
Vitreous samples from 48 PDR, 17 PVR and 30 RD patients were studied by enzyme-linked immunosorbent assay.
OPN, HMGB1, CTGF, and PEDF levels were significantly higher in PDR patients than in RD patients (P<0.001; 0.002; <0.001; <0.001, resp.).
CTGF and PEDF levels were significantly higher in PVR patients than in RD patients (P<0.001;0.004, resp.).
Exploratory logistic regression analysis identified significant associations between PDR and high levels of HMGB1, CTGF and PEDF, between PDR with active neovascularization and high levels of CTGF and PEDF, and between PDR with traction retinal detachment and high levels of HMGB1.
In patients with PDR, there were significant correlations between the levels of PEDF and the levels of OPN (r=0.544,P=0.001), HMGB1 (r=0.719,P<0.001), and CTGF (r=0.715,P<0.001).
In patients with PVR, there were significant correlations between the levels of OPN and the levels of HMGB1 (r=0.484,P=0.049) and PEDF (r=0.559,P=0.02).
Our findings suggest that OPN, HMGB1, and CTGF contribute to the pathogenesis of proliferative vitreoretinal disorders and that increased levels of PEDF may be a response to counterbalance the activity of angiogenic and fibrogenic factors in PDR and PVR.
American Psychological Association (APA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. 2012. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
Modern Language Association (MLA)
Abu El-Asrar, Ahmed M.…[et al.]. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
American Medical Association (AMA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. Osteopontin and Other Regulators of Angiogenesis and Fibrogenesis in the Vitreous from Patients with Proliferative Vitreoretinal Disorders. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001156