Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response
Joint Authors
Kobbe, Philipp
Lichte, Philipp
Schreiber, Helen
Reiss, Lucy Kathleen
Uhlig, Stefan
Pape, Hans-Christoph
Pfeifer, Roman
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Several studies report immunomodulatory effects of endogenous IL-10 after trauma.
The present study investigates the effect of inhalative IL-10 administration on systemic and pulmonary inflammation in hemorrhagic shock.
Male C57/BL6 mice (8 animals per group) were subjected to pressure-controlled hemorrhagic shock for 1.5 hrs followed by resuscitation and inhalative administration of either 50 μL PBS (Shock group) or 50 μg/kg recombinant mouse IL-10 dissolved in 50 μL PBS (Shock + IL-10 group).
Animals were sacrificed after 4.5 hrs of recovery and serum IL-6, IL-10, KC, and MCP-1 concentrations were measured with ELISA kits.
Acute pulmonary inflammation was assessed by pulmonary myeloperoxidase (MPO) activity and pulmonary H&E histopathology.
Inhalative IL-10 administration decreased pulmonary inflammation without altering the systemic concentrations of IL-6, IL-10, and KC.
Serum MCP-1 levels were significantly reduced following inhalative IL-10 administration.
These findings suggest that inhalative IL-10 administration may modulate the pulmonary microenvironment without major alterations of the systemic inflammatory response, thus minimizing the potential susceptibility to infection and sepsis.
American Psychological Association (APA)
Kobbe, Philipp& Lichte, Philipp& Schreiber, Helen& Reiss, Lucy Kathleen& Uhlig, Stefan& Pape, Hans-Christoph…[et al.]. 2011. Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001165
Modern Language Association (MLA)
Kobbe, Philipp…[et al.]. Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1001165
American Medical Association (AMA)
Kobbe, Philipp& Lichte, Philipp& Schreiber, Helen& Reiss, Lucy Kathleen& Uhlig, Stefan& Pape, Hans-Christoph…[et al.]. Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response. Mediators of Inflammation. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001165