Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells
Joint Authors
Kwak, Eun Jung
Lee, Young Soon
Choi, Eun Mi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
|Objectives.
In the present study, the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to stimulate osteoblast function and inhibit the release of bone-resorbing mediators was investigated in osteoblastic MC3T3-E1 cells.
Methods.
Osteoblast function was measured by cell growth, alkaline phosphatase activity, collagen synthesis, and mineralization.
Glutathione content was also measured in the cells.
Bone-resorbing cytokines, receptor activator of nuclear factor-κB ligand (RANKL), TNF-α, and IL-6 were measured with an enzyme immunoassay system.
Results.
Magnolol caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis, mineralization, and glutathione content in the cells (P<0.05).
Skeletal turnover is orchestrated by a complex network of regulatory factors.
Among cytokines, RANKL, TNF-α, and IL-6 were found to be key osteoclastogenetic molecules produced by osteoblasts.
Magnolol significantly (P<0.05) decreased the production of osteoclast differentiation inducing factors such as RANKL, TNF-α, and IL-6 in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as an ROS generator.
Conclusion.
Magnolol might be a candidate as an agent for the prevention of bone disorders such as osteoporosis.
American Psychological Association (APA)
Kwak, Eun Jung& Lee, Young Soon& Choi, Eun Mi. 2012. Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1001237
Modern Language Association (MLA)
Kwak, Eun Jung…[et al.]. Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1001237
American Medical Association (AMA)
Kwak, Eun Jung& Lee, Young Soon& Choi, Eun Mi. Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1001237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001237