PGI2 as a Regulator of Inflammatory Diseases
Joint Authors
Dorris, Stacy L.
Peebles, R. Stokes
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prostacyclin, or PGI2, is an end product derived from the sequential metabolism of arachidonic acid via cyclooxygenase and PGI synthase (PGIS).
The receptor for PGI2, IP, can be found on a variety of cell types and signaling through this receptor exhibits broad physiological effects.
Historically, PGI2 has been understood to play a role in cardiovascular health, specifically having powerful vasodilatory effects via relaxation of smooth muscle and inhibiting of platelet aggregation.
For these reasons, PGI2 has a long history of use for the treatment of pulmonary arterial hypertension (PAH).
Only recently, its importance as an immunomodulatory agent has been investigated.
PGI2 regulates both the innate and adaptive immune systems and its effects are, for the most part, thought to be anti-inflammatory or immunosuppressive in nature, which may have implications for its further clinical use.
American Psychological Association (APA)
Dorris, Stacy L.& Peebles, R. Stokes. 2012. PGI2 as a Regulator of Inflammatory Diseases. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001252
Modern Language Association (MLA)
Dorris, Stacy L.& Peebles, R. Stokes. PGI2 as a Regulator of Inflammatory Diseases. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1001252
American Medical Association (AMA)
Dorris, Stacy L.& Peebles, R. Stokes. PGI2 as a Regulator of Inflammatory Diseases. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001252