Divergent Roles of p75NTR and Trk Receptors in BDNF’s Effects on Dendritic Spine Density and Morphology
Joint Authors
Pozzo-Miller, Lucas
Chapleau, Christopher A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Activation of TrkB receptors by brain-derived neurotrophic factor (BDNF) followed by MAPK/ERK signaling increases dendritic spine density and the proportion of mature spines in hippocampal CA1 pyramidal neurons.
Considering the opposing actions of p75NTR and Trk receptors in several BDNF actions on CNS neurons, we tested whether these receptors also have divergent actions on dendritic spine density and morphology.
A function-blocking anti-p75NTR antibody (REX) did not affect spine density by itself but it prevented BDNF’s effect on spine density.
Intriguingly, REX by itself increased the proportion of immature spines and prevented BDNF’s effect on spine morphology.
In contrast, the Trk receptor inhibitor k-252a increased spine density by itself, and prevented BDNF from further increasing spine density.
However, most of the spines in k-252a-treated slices were of the immature type.
These effects of k-252a on spine density and morphology required neuronal activity because they were prevented by TTX.
These divergent BDNF actions on spine density and morphology are reminiscent of opposing functional signaling by p75NTR and Trk receptors and reveal an unexpected level of complexity in the consequences of BDNF signaling on dendritic morphology.
American Psychological Association (APA)
Chapleau, Christopher A.& Pozzo-Miller, Lucas. 2012. Divergent Roles of p75NTR and Trk Receptors in BDNF’s Effects on Dendritic Spine Density and Morphology. Neural Plasticity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002434
Modern Language Association (MLA)
Chapleau, Christopher A.& Pozzo-Miller, Lucas. Divergent Roles of p75NTR and Trk Receptors in BDNF’s Effects on Dendritic Spine Density and Morphology. Neural Plasticity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1002434
American Medical Association (AMA)
Chapleau, Christopher A.& Pozzo-Miller, Lucas. Divergent Roles of p75NTR and Trk Receptors in BDNF’s Effects on Dendritic Spine Density and Morphology. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002434