Ex Vivo Expansion of Human Mesenchymal Stem Cells in Defined Serum-Free Media
Joint Authors
Jung, Sunghoon
Panchalingam, Krishna M.
Rosenberg, Lawrence
Behie, Leo A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
21
Abstract EN
Human mesenchymal stem cells (hMSCs) are presently being evaluated for their therapeutic potential in clinical studies to treat various diseases, disorders, and injuries.
To date, early-phase studies have indicated that the use of both autologous and allogeneic hMSCs appear to be safe; however, efficacy has not been demonstrated in recent late-stage clinical trials.
Optimized cell bioprocessing protocols may enhance the efficacy as well as safety of hMSC therapeutics.
Classical media used for generating hMSCs are typically supplemented with ill-defined supplements such as fetal bovine serum (FBS) or human-sourced alternatives.
Ideally, culture media are desired to have well-defined serum-free formulations that support the efficient production of hMSCs while maintaining their therapeutic and differentiation capacity.
Towards this objective, we review here current cell culture media for hMSCs and discuss medium development strategies.
American Psychological Association (APA)
Jung, Sunghoon& Panchalingam, Krishna M.& Rosenberg, Lawrence& Behie, Leo A.. 2012. Ex Vivo Expansion of Human Mesenchymal Stem Cells in Defined Serum-Free Media. Stem Cells International،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-1002950
Modern Language Association (MLA)
Jung, Sunghoon…[et al.]. Ex Vivo Expansion of Human Mesenchymal Stem Cells in Defined Serum-Free Media. Stem Cells International No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-1002950
American Medical Association (AMA)
Jung, Sunghoon& Panchalingam, Krishna M.& Rosenberg, Lawrence& Behie, Leo A.. Ex Vivo Expansion of Human Mesenchymal Stem Cells in Defined Serum-Free Media. Stem Cells International. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-1002950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002950