Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model
Joint Authors
Sandvei Skeie, Bente
Wang, Jian
Dodoo, Ernest
Heggdal, Jan Ingeman
Grønli, Janne
Sleire, Linda
Bragstad, Sidsel
Ganz, Jeremy C.
Chekenya, Martha
Mørk, Sverre
Pedersen, Paal-Henning
Enger, Per Øyvind
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Object.
Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs).
However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of established treatments.
Thus, we developed an experimental brain tumor model to assess the efficacy and radiotoxicity associated with GKS.
Methods.
GBM xenografts were implanted intracerebrally in nude rats, and engraftment was confirmed with MRI.
The rats were allocated to GKS, with margin doses of 12 Gy or 18 Gy, or to no treatment.
Survival time was recorded, tumor sections were examined, and radiotoxicity was evaluated in a behavioral open field test.
Results.
In the first series, survival from the time of implantation was 96 days in treated rats and 72 days in controls (P<0.001).
In a second experiment, survival was 72 days in the treatment group versus 54 days in controls (P<0.006).
Polynuclear macrophages and fibrosis was seen in groups subjected to GKS.
Untreated rats with GBM xenografts displayed less mobility than GKS-treated animals in the open field test 4 weeks after treatment (P=0.04).
Conclusion.
GKS administered with clinically relevant doses prolongs survival in rats harboring GBM xenografts, and the associated toxicity is mild.
American Psychological Association (APA)
Sandvei Skeie, Bente& Wang, Jian& Dodoo, Ernest& Heggdal, Jan Ingeman& Grønli, Janne& Sleire, Linda…[et al.]. 2013. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
Modern Language Association (MLA)
Sandvei Skeie, Bente…[et al.]. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
American Medical Association (AMA)
Sandvei Skeie, Bente& Wang, Jian& Dodoo, Ernest& Heggdal, Jan Ingeman& Grønli, Janne& Sleire, Linda…[et al.]. Gamma Knife Surgery as Monotherapy with Clinically Relevant Doses Prolongs Survival in a Human GBM Xenograft Model. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1003360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003360