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INF-α and Ototoxicity
Joint Authors
Sharifian, Mohammad Reza
Kamandi, Shima
Sima, Hamid Reza
Zaringhalam, Mohammad Ali
Bakhshaee, Mehdi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
INF-α is a common drug for the treatment of hepatitis B and C.
Although a variety of related complications are discussed, possible ototoxic effects of this mediation are not well described.
Methods and Materials.
In a before-after control study, 24 patients who received INF-α for the treatment of hepatitis B and C and 30 normal controls were included.
Subjective and objective ototoxicity evaluations via questionnaire, high frequency audiometry, and measuring transiently evoked otoacoustic emissions (TEOAEs) were performed one week before and one month after the prescription of the drug.
Results.
Subjective hearing complaint, tinnitus, and vertigo were seen in just 3 cases, which was not statistically significant (P=0.083).
In the frequency range of 4000 to 8000 Hz before (9.38 ± 1.0 and 10.7 ± 1.2, resp.) and after (17.9 ± 2.6 and 17.6 ± 2.6, resp.) one month of treatment, a significant difference (P=0.083) was detected.
Progressive decreases in amplitude of the OAE during TEOAE measurement in 1, 2, and 4 frequencies among 41.66%, 18.75 %, and 43.75% were observed, respectively.
The hearing loss was seen more among older and male cases significantly.
Conclusion.
The results showed ototoxicity of INF-α that may encourage planning hearing monitoring in patients receiving this drug.
American Psychological Association (APA)
Sharifian, Mohammad Reza& Kamandi, Shima& Sima, Hamid Reza& Zaringhalam, Mohammad Ali& Bakhshaee, Mehdi. 2013. INF-α and Ototoxicity. BioMed Research International،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1003930
Modern Language Association (MLA)
Sharifian, Mohammad Reza…[et al.]. INF-α and Ototoxicity. BioMed Research International No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1003930
American Medical Association (AMA)
Sharifian, Mohammad Reza& Kamandi, Shima& Sima, Hamid Reza& Zaringhalam, Mohammad Ali& Bakhshaee, Mehdi. INF-α and Ototoxicity. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1003930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1003930