Antimicrobial Activity, Growth Inhibition of Human Tumour Cell Lines, and Phytochemical Characterization of the Hydromethanolic Extract Obtained from Sapindus saponaria L. Aerial Parts
Joint Authors
Calhelha, Ricardo C.
Rashed, Khaled N.
Ćirić, Ana
Glamočlija, Jasmina
Soković, Marina
Ferreira, Isabel C. F. R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The hydromethanolic extract of Sapindus saponaria L.
aerial parts was investigated for antimicrobial activity (against several Gram-positive and Gram-negative bacteria and fungi) and capacity to inhibit the growth of different human tumor cell lines as also nontumor liver cells.
The evaluated extract was further characterized in terms of phytochemicals using UV, 1H-NMR, 13C-NMR, and MS spectroscopic tools.
The extract has shown a significant antimicrobial activity on all tested bacterial and fungal species.
The best activity was achieved against Bacillus cereus and Staphylococcus aureus among bacteria and against all three Penicillium species tested.
It also revealed cytotoxicity against human colon (HCT-15), cervical (HeLa), breast (MCF-7), and lung (NCI-H460) carcinoma cell lines, with HeLa being the most susceptible tumor cell line.
The extract was not toxic for nontumor liver cells.
Chromatographic separation of the extract resulted in the isolation and identification of stigmasterol, oleanolic acid, luteolin, luteolin 8-C-β-glucoside (orientin), luteolin 6-C-β-glucoside (isoorientin), luteolin 7-O-β-glucuronide, and rutin.
The results of the present findings may be useful for the discovery of novel antitumor and antimicrobial agents from plant origin.
American Psychological Association (APA)
Rashed, Khaled N.& Ćirić, Ana& Glamočlija, Jasmina& Calhelha, Ricardo C.& Ferreira, Isabel C. F. R.& Soković, Marina. 2013. Antimicrobial Activity, Growth Inhibition of Human Tumour Cell Lines, and Phytochemical Characterization of the Hydromethanolic Extract Obtained from Sapindus saponaria L. Aerial Parts. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004820
Modern Language Association (MLA)
Rashed, Khaled N.…[et al.]. Antimicrobial Activity, Growth Inhibition of Human Tumour Cell Lines, and Phytochemical Characterization of the Hydromethanolic Extract Obtained from Sapindus saponaria L. Aerial Parts. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1004820
American Medical Association (AMA)
Rashed, Khaled N.& Ćirić, Ana& Glamočlija, Jasmina& Calhelha, Ricardo C.& Ferreira, Isabel C. F. R.& Soković, Marina. Antimicrobial Activity, Growth Inhibition of Human Tumour Cell Lines, and Phytochemical Characterization of the Hydromethanolic Extract Obtained from Sapindus saponaria L. Aerial Parts. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1004820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004820