Microenvironment and Radiation Therapy
Joint Authors
Yoshimura, Michio
Itasaka, Satoshi
Harada, Hiroshi
Hiraoka, Masahiro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia.
The first approach to overcome tumor hypoxia was to improve tumor oxygenation by increasing oxygen delivery and a subsequent approach was the use of radiosensitizers in combination with radiation therapy.
Clinical use of some of these approaches was promising, but they are not widely used due to several limitations.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is activated by hypoxia and induces the expression of various genes related to the adaptation of cellular metabolism to hypoxia, invasion and metastasis of cancer cells and angiogenesis, and so forth.
HIF-1 is a potent target to enhance the therapeutic effects of radiation therapy.
Another approach is antiangiogenic therapy.
The combination with radiation therapy is promising, but several factors including surrogate markers, timing and duration, and so forth have to be optimized before introducing it into clinics.
In this review, we examined how the tumor microenvironment influences the effects of radiation and how we can enhance the antitumor effects of radiation therapy by modifying the tumor microenvironment.
American Psychological Association (APA)
Yoshimura, Michio& Itasaka, Satoshi& Harada, Hiroshi& Hiraoka, Masahiro. 2012. Microenvironment and Radiation Therapy. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1004859
Modern Language Association (MLA)
Yoshimura, Michio…[et al.]. Microenvironment and Radiation Therapy. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1004859
American Medical Association (AMA)
Yoshimura, Michio& Itasaka, Satoshi& Harada, Hiroshi& Hiraoka, Masahiro. Microenvironment and Radiation Therapy. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1004859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1004859