An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction
Joint Authors
Chaudhary, Amit Kumar
Dhakal, Dipesh
Sohng, Jae Kyung
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Microorganisms produce a range of chemical substances representing a vast diversity of fascinating molecular architectures not available in any other system.
Among them, Streptomyces are frequently used to produce useful enzymes and a wide variety of secondary metabolites with potential biological activities.
Streptomyces are preferred over other microorganisms for producing more than half of the clinically useful naturally originating pharmaceuticals.
However, these compounds are usually produced in very low amounts (or not at all) under typical laboratory conditions.
Despite the superiority of Streptomyces, they still lack well documented genetic information and a large number of in-depth molecular biological tools for strain improvement.
Previous attempts to produce high yielding strains required selection of the genetic material through classical mutagenesis for commercial production of secondary metabolites, optimizing culture conditions, and random selection.
However, a profound effect on the strategy for strain development has occurred with the recent advancement of whole-genome sequencing, systems biology, and genetic engineering.
In this review, we demonstrate a few of the major issues related to the potential of “-omics” technology (genomics, transcriptomics, proteomics, and metabolomics) for improving streptomycetes as an intelligent chemical factory for enhancing the production of useful bioactive compounds.
American Psychological Association (APA)
Chaudhary, Amit Kumar& Dhakal, Dipesh& Sohng, Jae Kyung. 2013. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
Modern Language Association (MLA)
Chaudhary, Amit Kumar…[et al.]. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
American Medical Association (AMA)
Chaudhary, Amit Kumar& Dhakal, Dipesh& Sohng, Jae Kyung. An Insight into the “-Omics” Based Engineering of Streptomycetes for Secondary Metabolite Overproduction. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1005536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005536