Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis
Joint Authors
Sun, Jian-Min
Sun, Liang-Zhi
Liu, Jun
Su, Bao-hui
Shi, Lin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Inflammation plays a crucial role in the development and progression of osteoarthritis (OA).
Interleukin-15 (IL-15) is a well-known proinflammatory cytokine.
Objective.
We aimed at evaluating the relationship between serum IL-15 levels and the severity of pain as well as radiographic progression in patients with knee OA.
Methods.
Two hundred and twenty-six OA patients and 106 controls were enrolled in this study.
The symptomatic/radiological severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index- (WOMAC-)pain scores/Kellgren-Lawrence (KL) grading system.
Serum IL-15 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results.
Serum IL-15 levels were significantly higher in OA patients compared with controls.
Serum IL-15 levels were independently and positively correlated with WOMAC-pain scores but not KL grades in OA patients.
Conclusions.
We demonstrated that increased serum IL-15 levels were independently correlated with self-reported greater pain in knee OA patients.
These results suggest that IL-15 might play a crucial role in the pathogenesis of OA related pain and therapeutic interventions by blocking IL-15 signaling pathways to delay the degenerative process of OA related pain which warrants further investigations.
American Psychological Association (APA)
Sun, Jian-Min& Sun, Liang-Zhi& Liu, Jun& Su, Bao-hui& Shi, Lin. 2013. Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis. Disease Markers،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005794
Modern Language Association (MLA)
Sun, Jian-Min…[et al.]. Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis. Disease Markers No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-1005794
American Medical Association (AMA)
Sun, Jian-Min& Sun, Liang-Zhi& Liu, Jun& Su, Bao-hui& Shi, Lin. Serum Interleukin-15 Levels Are Associated with Severity of Pain in Patients with Knee Osteoarthritis. Disease Markers. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-1005794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1005794