Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs
Joint Authors
Rodríguez-Lázaro, D.
Martínez-Martínez, S.
Hernández, M.
Gutiérrez-Martín, C. B.
Rodríguez-Ferri, E. F.
Yubero, S.
Frandoloso, R.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The expression of chemokines (CCL-2 and CXCL-8) and cytokines (IL-1α, IL-1β, IL-6, TNF-α, and IL-10) was evaluated by RT-qPCR in colostrum-deprived pigs vaccinated and challenged with Haemophilus parasuis serovar 5.
Two vaccines containing native proteins with affinity to porcine transferrin (NPAPTim and NPAPTit) were tested, along with two control groups: one inoculated with PBS instead of antigen (challenge group (CHG)), and another one nonimmunized and noninfected (blank group).
The use of NPAPTim and NPAPTit resulted in complete protection against H.
parasuis (no clinical signs and/or lesions), and both vaccines were capable of avoiding the expression of the proinflammatory molecules to levels similar to physiological values in blank group.
However, overexpression of all proinflammatory molecules was observed in CHG group, mainly in the target infection tissues (brain, lungs, and spleen).
High expression of CCL-2, CXCL-8, IL-1α, IL-1β, and IL-6 can be considered one of the characteristics of H.
parasuis infection by serovar 5.
American Psychological Association (APA)
Frandoloso, R.& Martínez-Martínez, S.& Rodríguez-Ferri, E. F.& Rodríguez-Lázaro, D.& Hernández, M.& Gutiérrez-Martín, C. B.…[et al.]. 2013. Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006441
Modern Language Association (MLA)
Rodríguez-Lázaro, D.…[et al.]. Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs. Journal of Immunology Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1006441
American Medical Association (AMA)
Frandoloso, R.& Martínez-Martínez, S.& Rodríguez-Ferri, E. F.& Rodríguez-Lázaro, D.& Hernández, M.& Gutiérrez-Martín, C. B.…[et al.]. Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin Prevent the Expression of Proinflammatory Chemokines and Cytokines in Pigs. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1006441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006441