Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications
Joint Authors
de Moerloose, P.
Cohen, Marie
Marchetti, T.
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations associated with the presence of antiphospholipid antibodies (aPL) in patient plasma.
Obstetrical APS is a complex entity that may affect both mother and fetus throughout the entire pregnancy with high morbidity.
Clinical complications are as various as recurrent fetal losses, stillbirth, intrauterine growth restriction (IUGR), and preeclampsia.
Pathogenesis of aPL targets trophoblastic cells directly, mainly via proapoptotic, proinflammatory mechanisms, and uncontrolled immunomodulatory responses.
Actual first-line treatment is limited to low-dose aspirin (LDA) and low-molecular weight heparin (LMWH) and still failed in 30% of the cases.
APS pregnancies should be a major field in obstetrical research, and new therapeutics are still in progress.
American Psychological Association (APA)
Marchetti, T.& Cohen, Marie& de Moerloose, P.. 2013. Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006460
Modern Language Association (MLA)
Marchetti, T.…[et al.]. Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006460
American Medical Association (AMA)
Marchetti, T.& Cohen, Marie& de Moerloose, P.. Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006460