Nuclear Antigens and AutoAlloantibody Responses: Friend or Foe in Transplant Immunology
Joint Authors
Nakano, Toshiaki
Chen, Chao-Long
Goto, Shigeru
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In addition to cellular immune responses, humoral immune responses, mediated by natural antibodies, autoantibodies, and alloantibodies, have increasingly been recognized as causes of organ transplant rejection.
In our previous studies, we have demonstrated the induction of antinuclear antibodies against histone H1 and high-mobility group box 1 (HMGB1), in both experimental and clinical liver transplant tolerance.
The active induction of antinuclear antibodies is usually an undesirable phenomenon, but it is often observed after liver transplantation.
However, the release of nuclear antigens and its suppression by neutralizing antibodies are proposed to be important in the initiation and regulation of immune responses.
In this review article, we summarize the current understanding of nuclear antigens and corresponding antinuclear regulatory antibodies (Abregs) on infection, injury, inflammation, transplant rejection, and tolerance induction and discuss the significance of nuclear antigens as diagnostic and therapeutic targets.
American Psychological Association (APA)
Nakano, Toshiaki& Chen, Chao-Long& Goto, Shigeru. 2013. Nuclear Antigens and AutoAlloantibody Responses: Friend or Foe in Transplant Immunology. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006540
Modern Language Association (MLA)
Nakano, Toshiaki…[et al.]. Nuclear Antigens and AutoAlloantibody Responses: Friend or Foe in Transplant Immunology. Journal of Immunology Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1006540
American Medical Association (AMA)
Nakano, Toshiaki& Chen, Chao-Long& Goto, Shigeru. Nuclear Antigens and AutoAlloantibody Responses: Friend or Foe in Transplant Immunology. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1006540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006540