Interferon-γ Triggers Hepatic Stellate Cell-Mediated Immune Regulation through MEKERK Signaling Pathway
Joint Authors
Lu, Lina
Gu, Xiaodong
Wang, Yan
Chen, Zongyou
Qian, Shiguang
Xiang, Jianbin
Wang, Lianfu
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hepatic stellate cells (HSCs) interact with immune cells to actively participate in regulating immune response in the liver which is mediated by the effector molecules, including B7-H1.
We demonstrated here that expression of B7-H1 on HSCs was markedly enhanced by interferon-(IFN-) γ stimulation.
IFN-γ stimulated HSCs inhibited T-cell proliferation via induction of T-cell apoptosis (22.1% ± 1.6%).
This immunosuppressive effect was inhibited by preincubation with an anti-B7-H1 antibody, or inhibitor of the MEK/ERK pathway inhibited IFN-γ mediated expression of B7-H1.
Thus, regulation of B7-H1 expression on HSCs by IFN-γ represents an important mechanism that regulates immune responses in the liver favoring tolerogenicity rather than immunogenicity.
Involvement of MEK/ERK pathway provides a novel target for therapeutic approaches.
American Psychological Association (APA)
Gu, Xiaodong& Wang, Yan& Xiang, Jianbin& Chen, Zongyou& Wang, Lianfu& Lu, Lina…[et al.]. 2013. Interferon-γ Triggers Hepatic Stellate Cell-Mediated Immune Regulation through MEKERK Signaling Pathway. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006671
Modern Language Association (MLA)
Gu, Xiaodong…[et al.]. Interferon-γ Triggers Hepatic Stellate Cell-Mediated Immune Regulation through MEKERK Signaling Pathway. Journal of Immunology Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1006671
American Medical Association (AMA)
Gu, Xiaodong& Wang, Yan& Xiang, Jianbin& Chen, Zongyou& Wang, Lianfu& Lu, Lina…[et al.]. Interferon-γ Triggers Hepatic Stellate Cell-Mediated Immune Regulation through MEKERK Signaling Pathway. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1006671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006671