Microglia Play a Major Role in Direct Viral-Induced Demyelination
Joint Authors
Nag, Soma
Ramachandra, S. G.
Biswas, Kaushiki
Das Sarma, Jayasri
Chatterjee, Dhriti
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Microglia are the resident macrophage-like populations in the central nervous system (CNS).
Microglia remain quiescent, unable to perform effector and antigen presentation (APC) functions until activated by injury or infection, and have been suggested to represent the first line of defence for the CNS.
Previous studies demonstrated that microglia can be persistently infected by neurotropic mouse hepatitis virus (MHV) which causes meningoencephalitis, myelitis with subsequent axonal loss, and demyelination and serve as a virus-induced model of human neurological disease multiple sclerosis (MS).
Current studies revealed that MHV infection is associated with the pronounced activation of microglia during acute inflammation, as evidenced by characteristic changes in cellular morphology and increased expression of microglia-specific proteins, Iba1 (ionized calcium-binding adaptor molecule 1), which is a macrophage/microglia-specific novel calcium-binding protein and involved in membrane ruffling and phagocytosis.
During chronic inflammation (day 30 postinfection), microglia were still present within areas of demyelination.
Experiments performed in ex vivo spinal cord slice culture and in vitro neonatal microglial culture confirmed direct microglial infection.
Our results suggest that MHV can directly infect and activate microglia during acute inflammation, which in turn during chronic inflammation stage causes phagocytosis of myelin sheath leading to chronic inflammatory demyelination.
American Psychological Association (APA)
Chatterjee, Dhriti& Biswas, Kaushiki& Nag, Soma& Ramachandra, S. G.& Das Sarma, Jayasri. 2013. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006782
Modern Language Association (MLA)
Chatterjee, Dhriti…[et al.]. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Journal of Immunology Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1006782
American Medical Association (AMA)
Chatterjee, Dhriti& Biswas, Kaushiki& Nag, Soma& Ramachandra, S. G.& Das Sarma, Jayasri. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1006782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006782