What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?
Joint Authors
Ramos, Rodrigo Nalio
Zelante, Bruna
Barbuto, José Alexandre M.
Moraes, Cristiano Jacob de
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dendritic cells (DCs) are essential for the maintenance of homeostasis in the organism, and they do that by modulating lymphocyte priming, expansion, and response patterns according to signals they receive from the environment.
The induction of suppressive lymphocytes by DCs is essential to hinder the development of autoimmune diseases but can be reverted against homeostasis when in the context of neoplasia.
In this setting, the induction of suppressive or regulatory T cells contributes to the establishment of a state of tolerance towards the tumor, allowing it to grow unchecked by an otherwise functional immune system.
Besides affecting its local environment, tumor also has been described as potent sources of anti-inflammatory/suppressive factors, which may act systemically, generating defects in the differentiation and maturation of immune cells, far beyond the immediate vicinity of the tumor mass.
Cytokines, as IL-10 and TGF-beta, as well as cell surface molecules like PD-L1 and ICOS seem to be significantly involved in the redirection of DCs towards tolerance induction, and recent data suggest that tumor cells may, indeed, modulate distinct DCs subpopulations through the involvement of these molecules.
It is to be expected that the identification of such molecules should provide molecular targets for more effective immunotherapeutic approaches to cancer.
American Psychological Association (APA)
Ramos, Rodrigo Nalio& Moraes, Cristiano Jacob de& Zelante, Bruna& Barbuto, José Alexandre M.. 2013. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006927
Modern Language Association (MLA)
Ramos, Rodrigo Nalio…[et al.]. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Journal of Immunology Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1006927
American Medical Association (AMA)
Ramos, Rodrigo Nalio& Moraes, Cristiano Jacob de& Zelante, Bruna& Barbuto, José Alexandre M.. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1006927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006927