The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
Joint Authors
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil.
This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs.
The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed.
Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies.
American Psychological Association (APA)
Könnecke, Helen& Bechmann, Ingo. 2013. The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1006999
Modern Language Association (MLA)
Könnecke, Helen& Bechmann, Ingo. The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas. Journal of Immunology Research No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-1006999
American Medical Association (AMA)
Könnecke, Helen& Bechmann, Ingo. The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-1006999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1006999