Elevated 1-α Hydroxylase Activity in Monocytes from Patients with Active Tuberculosis
Joint Authors
Tung, Yi-Ching
Tsai, Wen-Chan
Ou, Tsan-Teng
Source
Journal of Immunology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A uremic patient developed hypercalcemia after tuberculosis infection, and his ionized calcium levels correlated with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) levels.
We performed further studies to determine whether monocytes are alternative sites of 1,25(OH)2D3 conversion beyond renal tubular cells.
Using an ex vivo bioassay, in this study, we found that 1-α hydroxylase (CYP27B1) activity in monocytes is significantly higher in patients with active tuberculosis (TB) than in those with frequent TB contact.
However, when monocytes from patients with active TB were restimulated with antigen derived from Mycobacterium tuberculosis, less 1,25(OH)2D3 was observed.
In contrast, the level of 1,25(OH)2D3 was unchanged in those with frequent TB contact.
We conclude that monocytes may be an alternative source of 1-α hydroxylase that could convert 25-hydroxyvitamin D3 to the more active 1,25(OH)2D3.
American Psychological Association (APA)
Tung, Yi-Ching& Ou, Tsan-Teng& Tsai, Wen-Chan. 2013. Elevated 1-α Hydroxylase Activity in Monocytes from Patients with Active Tuberculosis. Journal of Immunology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1007009
Modern Language Association (MLA)
Tung, Yi-Ching…[et al.]. Elevated 1-α Hydroxylase Activity in Monocytes from Patients with Active Tuberculosis. Journal of Immunology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1007009
American Medical Association (AMA)
Tung, Yi-Ching& Ou, Tsan-Teng& Tsai, Wen-Chan. Elevated 1-α Hydroxylase Activity in Monocytes from Patients with Active Tuberculosis. Journal of Immunology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1007009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1007009